Repeated heart rate variability monitoring after myocardial infraction – Cohort profile of the MI-ECG study
The purpose of this study was to monitor heart rate variability (HRV) parameters after myocardial infarction (MI), addressing the ongoing controversy regarding their prognostic value. HRV was measured via Holter monitoring during the acute phase around the time of discharge and again two weeks later...
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| Format: | Article |
| Language: | English |
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Elsevier
2025-04-01
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| Series: | International Journal of Cardiology: Heart & Vasculature |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S2352906725000223 |
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| author | Teemu Pukkila Jani Rankinen Leo-Pekka Lyytikäinen Niku Oksala Kjell Nikus Esa Räsänen Jussi Hernesniemi |
| author_facet | Teemu Pukkila Jani Rankinen Leo-Pekka Lyytikäinen Niku Oksala Kjell Nikus Esa Räsänen Jussi Hernesniemi |
| author_sort | Teemu Pukkila |
| collection | DOAJ |
| description | The purpose of this study was to monitor heart rate variability (HRV) parameters after myocardial infarction (MI), addressing the ongoing controversy regarding their prognostic value. HRV was measured via Holter monitoring during the acute phase around the time of discharge and again two weeks later during recovery. Our findings show that HRV parameters remained stable during the initial weeks post-MI, indicating that the timing of Holter monitoring in this period is not critical.Several HRV parameters were significantly correlated with MI type, Killip class, and left ventricular ejection fraction (LVEF), with reduced HRV observed in STEMI patients and those with decompensated heart failure. However, after adjusting for GRACE score and LVEF, the prognostic value of most HRV measures for predicting future cardiac events diminished. Notably, detrended fluctuation analysis DFA1 α2 yielded a significant hazard ratio (HR) of 0.79 when adjusted for the GRACE score. However, this significance diminished after adjusting for LVEF (HR = 0.84).In conclusion, HRV parameters reflect MI severity and correlate with clinical characteristics, but their independent predictive value for future cardiac events is limited when adjusted for established risk factors such as LVEF and GRACE score. |
| format | Article |
| id | doaj-art-43e148671e7b490e902db772a2e93ec7 |
| institution | Kabale University |
| issn | 2352-9067 |
| language | English |
| publishDate | 2025-04-01 |
| publisher | Elsevier |
| record_format | Article |
| series | International Journal of Cardiology: Heart & Vasculature |
| spelling | doaj-art-43e148671e7b490e902db772a2e93ec72025-01-27T04:22:02ZengElsevierInternational Journal of Cardiology: Heart & Vasculature2352-90672025-04-0157101619Repeated heart rate variability monitoring after myocardial infraction – Cohort profile of the MI-ECG studyTeemu Pukkila0Jani Rankinen1Leo-Pekka Lyytikäinen2Niku Oksala3Kjell Nikus4Esa Räsänen5Jussi Hernesniemi6Computational Physics Laboratory, Tampere University, P.O. Box 600 FI-33014 Tampere, Finland; Corresponding author at: Computational Physics Laboratory, Tampere University, P.O. Box 600, FI-33014, Tampere, Finland.Faculty of Medicine and Health Technology, Tampere University, Arvo Ylpön katu, 34 FI-33520 Tampere, Finland; Finnish Cardiovascular Research Center Tampere, Arvo Ylpön katu 34 FI-33520 Tampere, Finland; Heart Hospital, Tampere University Hospital, Elämänaukio 1 (N building) FI-33520 Tampere, FinlandFaculty of Medicine and Health Technology, Tampere University, Arvo Ylpön katu, 34 FI-33520 Tampere, Finland; Finnish Cardiovascular Research Center Tampere, Arvo Ylpön katu 34 FI-33520 Tampere, Finland; Heart Hospital, Tampere University Hospital, Elämänaukio 1 (N building) FI-33520 Tampere, FinlandFaculty of Medicine and Health Technology, Tampere University, Arvo Ylpön katu, 34 FI-33520 Tampere, Finland; Finnish Cardiovascular Research Center Tampere, Arvo Ylpön katu 34 FI-33520 Tampere, Finland; Centre for Vascular Surgery and Interventional Radiology, Tampere University Hospital, Arvo Ylpön katu 34 FI-33520 Tampere, FinlandFaculty of Medicine and Health Technology, Tampere University, Arvo Ylpön katu, 34 FI-33520 Tampere, Finland; Finnish Cardiovascular Research Center Tampere, Arvo Ylpön katu 34 FI-33520 Tampere, Finland; Heart Hospital, Tampere University Hospital, Elämänaukio 1 (N building) FI-33520 Tampere, FinlandComputational Physics Laboratory, Tampere University, P.O. Box 600 FI-33014 Tampere, FinlandFaculty of Medicine and Health Technology, Tampere University, Arvo Ylpön katu, 34 FI-33520 Tampere, Finland; Finnish Cardiovascular Research Center Tampere, Arvo Ylpön katu 34 FI-33520 Tampere, Finland; Heart Hospital, Tampere University Hospital, Elämänaukio 1 (N building) FI-33520 Tampere, FinlandThe purpose of this study was to monitor heart rate variability (HRV) parameters after myocardial infarction (MI), addressing the ongoing controversy regarding their prognostic value. HRV was measured via Holter monitoring during the acute phase around the time of discharge and again two weeks later during recovery. Our findings show that HRV parameters remained stable during the initial weeks post-MI, indicating that the timing of Holter monitoring in this period is not critical.Several HRV parameters were significantly correlated with MI type, Killip class, and left ventricular ejection fraction (LVEF), with reduced HRV observed in STEMI patients and those with decompensated heart failure. However, after adjusting for GRACE score and LVEF, the prognostic value of most HRV measures for predicting future cardiac events diminished. Notably, detrended fluctuation analysis DFA1 α2 yielded a significant hazard ratio (HR) of 0.79 when adjusted for the GRACE score. However, this significance diminished after adjusting for LVEF (HR = 0.84).In conclusion, HRV parameters reflect MI severity and correlate with clinical characteristics, but their independent predictive value for future cardiac events is limited when adjusted for established risk factors such as LVEF and GRACE score.http://www.sciencedirect.com/science/article/pii/S2352906725000223Heart rate variabilityHolter recordingElectrogardiographyMyocardial infarction |
| spellingShingle | Teemu Pukkila Jani Rankinen Leo-Pekka Lyytikäinen Niku Oksala Kjell Nikus Esa Räsänen Jussi Hernesniemi Repeated heart rate variability monitoring after myocardial infraction – Cohort profile of the MI-ECG study International Journal of Cardiology: Heart & Vasculature Heart rate variability Holter recording Electrogardiography Myocardial infarction |
| title | Repeated heart rate variability monitoring after myocardial infraction – Cohort profile of the MI-ECG study |
| title_full | Repeated heart rate variability monitoring after myocardial infraction – Cohort profile of the MI-ECG study |
| title_fullStr | Repeated heart rate variability monitoring after myocardial infraction – Cohort profile of the MI-ECG study |
| title_full_unstemmed | Repeated heart rate variability monitoring after myocardial infraction – Cohort profile of the MI-ECG study |
| title_short | Repeated heart rate variability monitoring after myocardial infraction – Cohort profile of the MI-ECG study |
| title_sort | repeated heart rate variability monitoring after myocardial infraction cohort profile of the mi ecg study |
| topic | Heart rate variability Holter recording Electrogardiography Myocardial infarction |
| url | http://www.sciencedirect.com/science/article/pii/S2352906725000223 |
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