Prostate cancer incidence and mortality linked to metalworking fluid exposure: a systematic review and meta-analysis
BackgroundProstate cancer is the second most diagnosed cancer in men globally, with high prevalence in North America, Europe, and Australia. Occupational exposures, including metalworking fluids (MWFs), have emerged as a potential risk factor for prostate cancer, yet comprehensive studies on this as...
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Frontiers Media S.A.
2025-01-01
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| Series: | Frontiers in Oncology |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fonc.2024.1491159/full |
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| author | Zahra Moradpour Amin Barik Goljamal Jorjani Mohammad Reza Taherian Sepideh Tousizadeh Sepideh Tousizadeh Aram Halimi Aram Halimi Yaser Soleimani Mobina Karimian Tina Khavari Fateme Azizi Kalankari Fatemeh Asadipour Mojtaba Azari Niloofar Yousefzadeh Shakouri Saeideh Karamian Nasser Bahari Alireza Mosavi Jarrahi |
| author_facet | Zahra Moradpour Amin Barik Goljamal Jorjani Mohammad Reza Taherian Sepideh Tousizadeh Sepideh Tousizadeh Aram Halimi Aram Halimi Yaser Soleimani Mobina Karimian Tina Khavari Fateme Azizi Kalankari Fatemeh Asadipour Mojtaba Azari Niloofar Yousefzadeh Shakouri Saeideh Karamian Nasser Bahari Alireza Mosavi Jarrahi |
| author_sort | Zahra Moradpour |
| collection | DOAJ |
| description | BackgroundProstate cancer is the second most diagnosed cancer in men globally, with high prevalence in North America, Europe, and Australia. Occupational exposures, including metalworking fluids (MWFs), have emerged as a potential risk factor for prostate cancer, yet comprehensive studies on this association are limited.ObjectiveThis study aims to systematically review and conduct a meta-analysis to examine the incidence and mortality of prostate cancer linked to MWF exposure.MethodsA systematic review and meta-analysis were conducted following the PRISMA guidelines. A comprehensive search strategy was developed to identify relevant studies from PubMed, Scopus, Embase, and Web of Science. Inclusion criteria encompassed studies reporting on the association between MWF exposure and prostate cancer incidence or mortality. Data extraction and risk of bias assessment were performed independently by two reviewers, with discrepancies resolved by a third reviewer. Statistical analyses were conducted using STATA version 17.ResultsThe search identified 1376 unique references, with 5 studies meeting the inclusion criteria for the meta-analysis. These studies, conducted in the USA, primarily involved auto workers and reported Standardized Mortality Ratio (SMR), Relative Risk (RR) and 95% Confidence Interval (95%CI) measures. Meta-analysis revealed an overall RR of 1.06 (95% CI: 1.01-1.11) for prostate cancer incidence and an overall SMR of 1.20 (95% CI: 1.09-1.31) for prostate cancer mortality, indicating a statistically significant increased risk and mortality among MWF-exposed workers.ConclusionsThese findings carry significant implications for workplace safety regulations. Given the observed association between MWF exposure and prostate cancer risk, it is imperative to minimize occupational exposure through the implementation of effective engineering controls, personal protective equipment, and substitution of less hazardous fluids. Regular health surveillance and education programs for workers in industries utilizing MWFs are also essential to mitigate risk. Additionally, regulatory agencies should consider revising exposure limits and safety guidelines to account for emerging evidence on the carcinogenic potential of newer MWF formulations. |
| format | Article |
| id | doaj-art-43d337ee5ba74bebb5b41e4bcd6acb58 |
| institution | Kabale University |
| issn | 2234-943X |
| language | English |
| publishDate | 2025-01-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Oncology |
| spelling | doaj-art-43d337ee5ba74bebb5b41e4bcd6acb582025-01-30T05:10:05ZengFrontiers Media S.A.Frontiers in Oncology2234-943X2025-01-011410.3389/fonc.2024.14911591491159Prostate cancer incidence and mortality linked to metalworking fluid exposure: a systematic review and meta-analysisZahra Moradpour0Amin Barik1Goljamal Jorjani2Mohammad Reza Taherian3Sepideh Tousizadeh4Sepideh Tousizadeh5Aram Halimi6Aram Halimi7Yaser Soleimani8Mobina Karimian9Tina Khavari10Fateme Azizi Kalankari11Fatemeh Asadipour12Mojtaba Azari13Niloofar Yousefzadeh Shakouri14Saeideh Karamian15Nasser Bahari16Alireza Mosavi Jarrahi17Department of Occupational Health Engineering, Environmental Health Research Center, Golestan University of Medical Sciences, Gorgan, IranDepartment of Health, Safety and Environment, School of Public Health and Safety, Shahid Beheshti University of Medical Sciences, Tehran, IranDepartment of Epidemiology, School of Public Health, Shahid Beheshti University of Medical Sciences, Tehran, IranStudent Research Committee, School of Public Health, Shahid Beheshti University of Medical Sciences, Tehran, IranStudent Research Committee, Shahrekord University of Medical Sciences, Shahrekord, IranDepartment of Environmental Health Engineering, School of Health, Shahrekord University of Medical Sciences, Shahrekord, IranDepartment of Epidemiology, School of Public Health, Shahid Beheshti University of Medical Sciences, Tehran, IranResearch Center for Social Determinants of Health, Research Institute for Metabolic and Obesity Disorders, Research Institute for Endocrine Sciences, Shahid Beheshti University of Medical Sciences, Tehran, IranMedical School, Shahid Beheshti University of Medical Sciences, Tehran, IranDepartment of Occupational Health Engineering, Student Research Committee, Sabzevar University of Medical Sciences, Sabzevar, IranDepartment of Health, Safety and Environment, School of Public Health and Safety, Shahid Beheshti University of Medical Sciences, Tehran, IranDepartment of Health, Safety and Environment, School of Public Health and Safety, Shahid Beheshti University of Medical Sciences, Tehran, IranDepartment of Health, Safety and Environment, School of Public Health and Safety, Shahid Beheshti University of Medical Sciences, Tehran, Iran0Student Research Committee, Tabriz University of Medical Sciences, Tabriz, IranMedical School, Shahid Beheshti University of Medical Sciences, Tehran, IranMedical School, Shahid Beheshti University of Medical Sciences, Tehran, IranMedical School, Shahid Beheshti University of Medical Sciences, Tehran, Iran1Department of Social Medicine, School of Public Health and Safety, Shahid Beheshti University of Medical Sciences, Tehran, IranBackgroundProstate cancer is the second most diagnosed cancer in men globally, with high prevalence in North America, Europe, and Australia. Occupational exposures, including metalworking fluids (MWFs), have emerged as a potential risk factor for prostate cancer, yet comprehensive studies on this association are limited.ObjectiveThis study aims to systematically review and conduct a meta-analysis to examine the incidence and mortality of prostate cancer linked to MWF exposure.MethodsA systematic review and meta-analysis were conducted following the PRISMA guidelines. A comprehensive search strategy was developed to identify relevant studies from PubMed, Scopus, Embase, and Web of Science. Inclusion criteria encompassed studies reporting on the association between MWF exposure and prostate cancer incidence or mortality. Data extraction and risk of bias assessment were performed independently by two reviewers, with discrepancies resolved by a third reviewer. Statistical analyses were conducted using STATA version 17.ResultsThe search identified 1376 unique references, with 5 studies meeting the inclusion criteria for the meta-analysis. These studies, conducted in the USA, primarily involved auto workers and reported Standardized Mortality Ratio (SMR), Relative Risk (RR) and 95% Confidence Interval (95%CI) measures. Meta-analysis revealed an overall RR of 1.06 (95% CI: 1.01-1.11) for prostate cancer incidence and an overall SMR of 1.20 (95% CI: 1.09-1.31) for prostate cancer mortality, indicating a statistically significant increased risk and mortality among MWF-exposed workers.ConclusionsThese findings carry significant implications for workplace safety regulations. Given the observed association between MWF exposure and prostate cancer risk, it is imperative to minimize occupational exposure through the implementation of effective engineering controls, personal protective equipment, and substitution of less hazardous fluids. Regular health surveillance and education programs for workers in industries utilizing MWFs are also essential to mitigate risk. Additionally, regulatory agencies should consider revising exposure limits and safety guidelines to account for emerging evidence on the carcinogenic potential of newer MWF formulations.https://www.frontiersin.org/articles/10.3389/fonc.2024.1491159/fullmetalworking fluidsprostate cancerSMRRRmortalitymorbidity |
| spellingShingle | Zahra Moradpour Amin Barik Goljamal Jorjani Mohammad Reza Taherian Sepideh Tousizadeh Sepideh Tousizadeh Aram Halimi Aram Halimi Yaser Soleimani Mobina Karimian Tina Khavari Fateme Azizi Kalankari Fatemeh Asadipour Mojtaba Azari Niloofar Yousefzadeh Shakouri Saeideh Karamian Nasser Bahari Alireza Mosavi Jarrahi Prostate cancer incidence and mortality linked to metalworking fluid exposure: a systematic review and meta-analysis Frontiers in Oncology metalworking fluids prostate cancer SMR RR mortality morbidity |
| title | Prostate cancer incidence and mortality linked to metalworking fluid exposure: a systematic review and meta-analysis |
| title_full | Prostate cancer incidence and mortality linked to metalworking fluid exposure: a systematic review and meta-analysis |
| title_fullStr | Prostate cancer incidence and mortality linked to metalworking fluid exposure: a systematic review and meta-analysis |
| title_full_unstemmed | Prostate cancer incidence and mortality linked to metalworking fluid exposure: a systematic review and meta-analysis |
| title_short | Prostate cancer incidence and mortality linked to metalworking fluid exposure: a systematic review and meta-analysis |
| title_sort | prostate cancer incidence and mortality linked to metalworking fluid exposure a systematic review and meta analysis |
| topic | metalworking fluids prostate cancer SMR RR mortality morbidity |
| url | https://www.frontiersin.org/articles/10.3389/fonc.2024.1491159/full |
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