Ca<sup>2+</sup>/Calmodulin-Dependent Protein Kinase II (CaMKII) Regulates Basal Cardiac Pacemaker Function: Pros and Cons

The spontaneous firing of the sinoatrial (SA) node, the physiological pacemaker of the heart, is generated within sinoatrial nodal cells (SANCs) and is regulated by a “coupled-clock” pacemaker system, which integrates a “membrane clock”, the ensemble of ion channel currents, and an intracellular “Ca...

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Bibliographic Details
Main Authors: Tatiana M. Vinogradova, Edward G. Lakatta
Format: Article
Language:English
Published: MDPI AG 2024-12-01
Series:Cells
Subjects:
Online Access:https://www.mdpi.com/2073-4409/14/1/3
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