TC2N maintains stem cell-like characteristics to accelerate lung carcinogenesis by blockade of dual specificity protein phosphatase 3

TC2N maintains stem cell-like characteristics to accelerate lung carcinogenesis by blockade of dual specificity protein phosphatase 3

Abstract Background Tandem C2 domains, nuclear (TC2N) is a protein that has been characterized to contain C2A domain, C2B domain, and a short C-terminus with a WHXL motif. In previous studies, we have uncovered the oncogenic role and mechanisms of TC2N in lung cancer: TC2N achieves this by inhibitin...

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Bibliographic Details
Main Authors: Jing Gu, Yang-fan Lv, Ji-ying Xia, Fu-hai Bai, Ji Gong, Guang-qiang Pan, Bo Liu, Lu Huang, Qiao-nan Guo, Xiang-lin Hao
Format: Article
Language:English
Published: BMC 2025-01-01
Series:Cell & Bioscience
Subjects:
TC2N
Lung cancer
DUSP3 phosphatase
Urethane
Tumorigenesis
Stemness
Online Access:https://doi.org/10.1186/s13578-025-01348-3
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