血清miR-491-5p和miR-21-5p对急性缺血性卒中患者静脉溶栓后出血转化的预测价值 Predictive Value of Serum miR-491-5p and miR-21-5p on Hemorrhagic Transformation after Intravenous Thrombolysis in Acute Ischemic Stroke Patients

血清miR-491-5p和miR-21-5p对急性缺血性卒中患者静脉溶栓后出血转化的预测价值 Predictive Value of Serum miR-491-5p and miR-21-5p on Hemorrhagic Transformation after Intravenous Thrombolysis in Acute Ischemic Stroke Patients

目的 探讨血清微小RNA（microRNA，miRNA/miR）中miR-491-5p、miR-21-5p对急性缺血性卒中（acute ischemic stroke，AIS）患者静脉溶栓后出血转化的预测价值。 方法 回顾性选取2021年1月—2023年2月南阳市中心医院收治的312例AIS静脉溶栓治疗患者为研究对象，按照静脉溶栓后24 h内出血转化发生情况分为出血转化组（66例）和非出血转化组（246例）。实时荧光定量PCR测定血清miR-491-5p、miR-21-5p表达水平。采用多因素logistic回归分析探讨AIS患者静脉溶栓后出血转化的独立危险因素，以ROC曲线分析血清miR-...

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Bibliographic Details
Main Author: 王笑寒1，潘燕1，张小林1，刘坦2 (WANG Xiaohan1, PAN Yan1, ZHANG Xiaolin1, LIU Tan2 )
Format: Article
Language:zho
Published: Editorial Department of Chinese Journal of Stroke 2024-12-01
Series:Zhongguo cuzhong zazhi
Subjects:
mir-491-5p
mir-21-5p
急性缺血性卒中
静脉溶栓
出血转化
预测价值
acute ischemic stroke
intravenous thrombolysis
hemorrhagic transformation
predictive value
Online Access:https://www.chinastroke.org.cn/CN/10.3969/j.issn.1673-5765.2024.12.011
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https://www.chinastroke.org.cn/CN/10.3969/j.issn.1673-5765.2024.12.011

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