Mechanical Force‐Induced cGAS Activation in Carcinoma Cells Facilitates Splenocytes into Liver to Drive Metastasis

Mechanical Force‐Induced cGAS Activation in Carcinoma Cells Facilitates Splenocytes into Liver to Drive Metastasis

Abstract Liver metastasis is the main cause of cancer‐related mortality. During the metastasis process, circulating carcinoma cells hardly pass through narrow capillaries, leading to nuclear deformation. However, the effects of nuclear deformation and its underlying mechanisms on metastasis need fur...

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Main Authors: Xurui Zhang, Na Huang, Yanhua Mu, Haiyan Chen, Mengchen Zhu, Shaoying Zhang, Pengfei Liu, Hailong Zhang, Huan Deng, Keping Feng, Qi Shang, Xi Liu, Chen Zhang, Mengjiao Shi, Lan Yang, Jin Sun, Guangyao Kong, Jing Geng, Shemin Lu, Zongfang Li
Format: Article
Language:English
Published: Wiley 2025-02-01
Series:Advanced Science
Subjects:
liver metastasis
splenocytes
mechanical force
nuclear deformation
cGAS activation
Online Access:https://doi.org/10.1002/advs.202401127
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https://doi.org/10.1002/advs.202401127

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