Tegaserod maleate exerts anti-tumor effects on prostate cancer via repressing sonic hedgehog signaling pathway
Abstract Prostate cancer (PCa) is a highly common type of malignancy and affects millions of men in the world since it is easy to recur or emerge therapy resistance. Therefore, it is urgent to find novel treatments for PCa patients. In the current study, we found that tegaserod maleate (TM), an FDA-...
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| Format: | Article |
| Language: | English |
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BMC
2025-01-01
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| Series: | Molecular Medicine |
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| Online Access: | https://doi.org/10.1186/s10020-025-01080-1 |
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| author | Maoping Cai Shengdong Ge Yaying Hong Yao Chen Yang-Zi Ren Dacai Zhong Mingkun Chen Yuan Liu Zhe-Sheng Chen Ninghan Feng Zhanghui Chen Shan-Chao Zhao |
| author_facet | Maoping Cai Shengdong Ge Yaying Hong Yao Chen Yang-Zi Ren Dacai Zhong Mingkun Chen Yuan Liu Zhe-Sheng Chen Ninghan Feng Zhanghui Chen Shan-Chao Zhao |
| author_sort | Maoping Cai |
| collection | DOAJ |
| description | Abstract Prostate cancer (PCa) is a highly common type of malignancy and affects millions of men in the world since it is easy to recur or emerge therapy resistance. Therefore, it is urgent to find novel treatments for PCa patients. In the current study, we found that tegaserod maleate (TM), an FDA-approved agent, inhibited proliferation, colony formation, migration as well as invasion, caused the arrest of the cell cycle, and promoted apoptosis of PCa cells in vitro. In addition, TM suppressed the tumor growth in the cell-derived xenograft (CDX) mouse model in vivo. Mechanistically, TM exerted anti-tumor effects via downregulating GLI2, and its downtream targets, thus inhibiting the sonic hedgehog (SHH) signaling pathway. In brief, our findings demonstrated that TM effectively inhibited the activities of PCa cells by suppressing the SHH signaling pathway and provided a potential new agent for the treatment of PCa. |
| format | Article |
| id | doaj-art-43a896c0c268485ab4a7cd0fbb6dc14a |
| institution | Kabale University |
| issn | 1528-3658 |
| language | English |
| publishDate | 2025-01-01 |
| publisher | BMC |
| record_format | Article |
| series | Molecular Medicine |
| spelling | doaj-art-43a896c0c268485ab4a7cd0fbb6dc14a2025-02-02T12:29:27ZengBMCMolecular Medicine1528-36582025-01-0131111210.1186/s10020-025-01080-1Tegaserod maleate exerts anti-tumor effects on prostate cancer via repressing sonic hedgehog signaling pathwayMaoping Cai0Shengdong Ge1Yaying Hong2Yao Chen3Yang-Zi Ren4Dacai Zhong5Mingkun Chen6Yuan Liu7Zhe-Sheng Chen8Ninghan Feng9Zhanghui Chen10Shan-Chao Zhao11Department of Urology, The Fifth Affiliated Hospital of Southern Medical UniversityDepartment of Urology, Nanfang Hospital, Southern Medical UniversityDepartment of Urology, Nanfang Hospital, Southern Medical UniversityCollege of Pulmonary and Critical Care Medicine, The 8th Medical Center of Chinese People’s Liberation Army (PLA) General HospitalDepartment of Oncology, The First Affiliated Hospital of Guangzhou University of Chinese MedicineZhanjiang Institute of Clinical Medicine, Central People’s Hospital of ZhanjiangThe Third Clinical College, Southern Medical UniversityDepartment of Urology, Nanfang Hospital, Southern Medical UniversityDepartment of Pharmaceutical Sciences, College of Pharmacy and Health Sciences, St. John’s UniversityDepartment of Urology, Jiangnan University Medical CenterZhanjiang Institute of Clinical Medicine, Central People’s Hospital of ZhanjiangDepartment of Urology, The Fifth Affiliated Hospital of Southern Medical UniversityAbstract Prostate cancer (PCa) is a highly common type of malignancy and affects millions of men in the world since it is easy to recur or emerge therapy resistance. Therefore, it is urgent to find novel treatments for PCa patients. In the current study, we found that tegaserod maleate (TM), an FDA-approved agent, inhibited proliferation, colony formation, migration as well as invasion, caused the arrest of the cell cycle, and promoted apoptosis of PCa cells in vitro. In addition, TM suppressed the tumor growth in the cell-derived xenograft (CDX) mouse model in vivo. Mechanistically, TM exerted anti-tumor effects via downregulating GLI2, and its downtream targets, thus inhibiting the sonic hedgehog (SHH) signaling pathway. In brief, our findings demonstrated that TM effectively inhibited the activities of PCa cells by suppressing the SHH signaling pathway and provided a potential new agent for the treatment of PCa.https://doi.org/10.1186/s10020-025-01080-1Prostate cancer (PCa)Tegaserod maleate (TM)Sonic hedgehog (SHH) signalingGLI2Treatment |
| spellingShingle | Maoping Cai Shengdong Ge Yaying Hong Yao Chen Yang-Zi Ren Dacai Zhong Mingkun Chen Yuan Liu Zhe-Sheng Chen Ninghan Feng Zhanghui Chen Shan-Chao Zhao Tegaserod maleate exerts anti-tumor effects on prostate cancer via repressing sonic hedgehog signaling pathway Molecular Medicine Prostate cancer (PCa) Tegaserod maleate (TM) Sonic hedgehog (SHH) signaling GLI2 Treatment |
| title | Tegaserod maleate exerts anti-tumor effects on prostate cancer via repressing sonic hedgehog signaling pathway |
| title_full | Tegaserod maleate exerts anti-tumor effects on prostate cancer via repressing sonic hedgehog signaling pathway |
| title_fullStr | Tegaserod maleate exerts anti-tumor effects on prostate cancer via repressing sonic hedgehog signaling pathway |
| title_full_unstemmed | Tegaserod maleate exerts anti-tumor effects on prostate cancer via repressing sonic hedgehog signaling pathway |
| title_short | Tegaserod maleate exerts anti-tumor effects on prostate cancer via repressing sonic hedgehog signaling pathway |
| title_sort | tegaserod maleate exerts anti tumor effects on prostate cancer via repressing sonic hedgehog signaling pathway |
| topic | Prostate cancer (PCa) Tegaserod maleate (TM) Sonic hedgehog (SHH) signaling GLI2 Treatment |
| url | https://doi.org/10.1186/s10020-025-01080-1 |
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