Rational Design of Biocompatible Ir(III) Photosensitizer to Overcome Drug‐Resistant Cancer via Oxidative Autophagy Inhibition

Rational Design of Biocompatible Ir(III) Photosensitizer to Overcome Drug‐Resistant Cancer via Oxidative Autophagy Inhibition

Abstract Autophagy is a crucial quality control mechanism that degrades damaged cellular components through lysosomal fusion with autophagosomes. However, elevated autophagy levels can promote drug resistance in cancer cells, enhancing their survival. Downregulation of autophagy through oxidative st...

Full description

Saved in:
Bibliographic Details
Main Authors: Mingyu Park, Jung Seung Nam, Taehyun Kim, Gwangsu Yoon, Seoyoon Kim, Chaiheon Lee, Chae Gyu Lee, Sungjin Park, Kochan S. Bejoymohandas, Jihyeon Yang, Yoon Hee Kwon, Yoo Jin Lee, Jeong Kon Seo, Duyoung Min, Taiho Park, Tae‐Hyuk Kwon
Format: Article
Language:English
Published: Wiley 2025-01-01
Series:Advanced Science
Subjects:
autophagy
drug‐resistance
Ir(III) complexes
oxidation
photodynamic therapy
protein modifications
Online Access:https://doi.org/10.1002/advs.202407236
Tags: Add Tag
No Tags, Be the first to tag this record!

Internet

https://doi.org/10.1002/advs.202407236

Similar Items