CD4 depletion in SIV-infected macaques results in macrophage and microglia infection with rapid turnover of infected cells.

CD4 depletion in SIV-infected macaques results in macrophage and microglia infection with rapid turnover of infected cells.

In rhesus macaques (RMs), experimental depletion of CD4+ T-cells prior to SIV infection results in higher viremia and emergence of CD4-independent SIV-envelopes. In this study we used the rhesus recombinant anti-CD4 antibody CD4R1 to deplete RM CD4+ T-cells prior to SIVmac251 infection and investiga...

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Main Authors: Luca Micci, Xavier Alvarez, Robin I Iriele, Alexandra M Ortiz, Emily S Ryan, Colleen S McGary, Claire Deleage, Brigitte B McAtee, Tianyu He, Cristian Apetrei, Kirk Easley, Savita Pahwa, Ronald G Collman, Cynthia A Derdeyn, Miles P Davenport, Jacob D Estes, Guido Silvestri, Andrew A Lackner, Mirko Paiardini
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2014-10-01
Series:PLoS Pathogens
Online Access:https://doi.org/10.1371/journal.ppat.1004467
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https://doi.org/10.1371/journal.ppat.1004467

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