Impact of Serum Nutritional Status on Physical Function in African American and Caucasian Stroke Survivors
Background. The purpose of this study is to compare serum nutritional profiles in chronic stroke survivors to a representative sample of US Adults (NHANESIII) and determine whether these serum markers differed by race and impact physical function in stroke. Methods. Fasting serum samples were collec...
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| Format: | Article |
| Language: | English |
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Wiley
2014-01-01
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| Series: | Stroke Research and Treatment |
| Online Access: | http://dx.doi.org/10.1155/2014/174308 |
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| author | Monica C. Serra Charlene E. Hafer-Macko Frederick M. Ivey Richard F. Macko Alice S. Ryan |
| author_facet | Monica C. Serra Charlene E. Hafer-Macko Frederick M. Ivey Richard F. Macko Alice S. Ryan |
| author_sort | Monica C. Serra |
| collection | DOAJ |
| description | Background. The purpose of this study is to compare serum nutritional profiles in chronic stroke survivors to a representative sample of US Adults (NHANESIII) and determine whether these serum markers differed by race and impact physical function in stroke. Methods. Fasting serum samples were collected for analysis of lipids, uric acid, and albumin in 145 African American (AA) and 111 Caucasian (C) stroke survivors (age: 60 ± 1 years [mean ± SEM]). A six-minute walk was performed in a subset of stroke survivors (N = 134). Results. Triglycerides were higher and HDL-cholesterol and albumin lower in C than AA women stroke survivors (Ps < 0.05). Uric acid was lower in C than AA stroke survivors (P < 0.05). Compared to NHANESIII, HDL-cholesterol, albumin, and hemoglobin generally were lower (Ps < 0.05) and lipids were more favorable in stroke (Ps < 0.01). Uric acid was related to six-minute walk performance among a subset of stroke survivors (P < 0.05). Conclusion. In stroke, racial differences exist with regard to serum nutritional risk, but these differences are similar to that observed in the general population. Regardless of race, nutritional risk appears elevated above that of the general population with regard to many of the serum markers. As a modifiable biomarker, uric acid should be monitored closely as it may provide insight into the functional risk of stroke survivors. |
| format | Article |
| id | doaj-art-430009e32ded473faafa440229e62e68 |
| institution | Kabale University |
| issn | 2090-8105 2042-0056 |
| language | English |
| publishDate | 2014-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Stroke Research and Treatment |
| spelling | doaj-art-430009e32ded473faafa440229e62e682025-02-03T00:58:55ZengWileyStroke Research and Treatment2090-81052042-00562014-01-01201410.1155/2014/174308174308Impact of Serum Nutritional Status on Physical Function in African American and Caucasian Stroke SurvivorsMonica C. Serra0Charlene E. Hafer-Macko1Frederick M. Ivey2Richard F. Macko3Alice S. Ryan4Department of Medicine, University of Maryland School of Medicine, 10 N Greene Street (BT/18/GR), Baltimore, MD 21201, USADepartment of Neurology, University of Maryland School of Medicine, Baltimore, MD 21201, USADepartment of Neurology, University of Maryland School of Medicine, Baltimore, MD 21201, USADepartment of Medicine, University of Maryland School of Medicine, 10 N Greene Street (BT/18/GR), Baltimore, MD 21201, USADepartment of Medicine, University of Maryland School of Medicine, 10 N Greene Street (BT/18/GR), Baltimore, MD 21201, USABackground. The purpose of this study is to compare serum nutritional profiles in chronic stroke survivors to a representative sample of US Adults (NHANESIII) and determine whether these serum markers differed by race and impact physical function in stroke. Methods. Fasting serum samples were collected for analysis of lipids, uric acid, and albumin in 145 African American (AA) and 111 Caucasian (C) stroke survivors (age: 60 ± 1 years [mean ± SEM]). A six-minute walk was performed in a subset of stroke survivors (N = 134). Results. Triglycerides were higher and HDL-cholesterol and albumin lower in C than AA women stroke survivors (Ps < 0.05). Uric acid was lower in C than AA stroke survivors (P < 0.05). Compared to NHANESIII, HDL-cholesterol, albumin, and hemoglobin generally were lower (Ps < 0.05) and lipids were more favorable in stroke (Ps < 0.01). Uric acid was related to six-minute walk performance among a subset of stroke survivors (P < 0.05). Conclusion. In stroke, racial differences exist with regard to serum nutritional risk, but these differences are similar to that observed in the general population. Regardless of race, nutritional risk appears elevated above that of the general population with regard to many of the serum markers. As a modifiable biomarker, uric acid should be monitored closely as it may provide insight into the functional risk of stroke survivors.http://dx.doi.org/10.1155/2014/174308 |
| spellingShingle | Monica C. Serra Charlene E. Hafer-Macko Frederick M. Ivey Richard F. Macko Alice S. Ryan Impact of Serum Nutritional Status on Physical Function in African American and Caucasian Stroke Survivors Stroke Research and Treatment |
| title | Impact of Serum Nutritional Status on Physical Function in African American and Caucasian Stroke Survivors |
| title_full | Impact of Serum Nutritional Status on Physical Function in African American and Caucasian Stroke Survivors |
| title_fullStr | Impact of Serum Nutritional Status on Physical Function in African American and Caucasian Stroke Survivors |
| title_full_unstemmed | Impact of Serum Nutritional Status on Physical Function in African American and Caucasian Stroke Survivors |
| title_short | Impact of Serum Nutritional Status on Physical Function in African American and Caucasian Stroke Survivors |
| title_sort | impact of serum nutritional status on physical function in african american and caucasian stroke survivors |
| url | http://dx.doi.org/10.1155/2014/174308 |
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