Berberine alleviates respiratory syncytial virus (RSV)-induced pediatric bronchiolitis and fibrosis via suppressing the HMGB1/TLR4/NF-κB pathway

Berberine alleviates respiratory syncytial virus (RSV)-induced pediatric bronchiolitis and fibrosis via suppressing the HMGB1/TLR4/NF-κB pathway

ABSTRACT Berberine exhibits antitumor, antibacterial, and antiviral properties. This study explored its therapeutic potential and molecular mechanism in respiratory syncytial virus (RSV)-induced pediatric bronchiolitis (PB). BEAS-2B cells were infected with RSV (multiplicity of infection = 0.5, 1.0,...

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Bibliographic Details
Main Authors: Yang Jiao, Rui Yang
Format: Article
Language:English
Published: American Society for Microbiology 2025-08-01
Series:Microbiology Spectrum
Subjects:
respiratory syncytial virus
pediatric bronchiolitis
berberine
inflammation
epithelial-mesenchymal transformation
Online Access:https://journals.asm.org/doi/10.1128/spectrum.00900-25
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