Clostridium difficile-derived membrane vesicles promote fetal growth restriction via inhibiting trophoblast motility through PPARγ/RXRα/ANGPTL4 axis

Clostridium difficile-derived membrane vesicles promote fetal growth restriction via inhibiting trophoblast motility through PPARγ/RXRα/ANGPTL4 axis

Abstract Fetal growth restriction (FGR) is a common complication of pregnancy, which seriously endangers fetal health and still lacks effective therapeutic targets. Clostridium difficile (C. difficile) is associated with fetal birth weight, and its membrane vesicles (MVs) are pathogenic vectors. How...

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Main Authors: Zhiqiang Zha, Chunhong Jia, Ruisi Zhou, Qinlan Yin, Yu Hu, Zhipeng Huang, Linyu Peng, Yichi Zhang, Xiaowei Qiu, Ying Chen, Yawen Zhong, Yu Wang, Menglan Pang, Shijing Lu, Chao Sheng, Liping Huang
Format: Article
Language:English
Published: Nature Portfolio 2024-12-01
Series:npj Biofilms and Microbiomes
Online Access:https://doi.org/10.1038/s41522-024-00630-5
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https://doi.org/10.1038/s41522-024-00630-5

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