Few shot learning for phenotype-driven diagnosis of patients with rare genetic diseases

Abstract There are over 7000 rare diseases, some affecting 3500 or fewer patients in the United States. Due to clinicians’ limited experience with such diseases and the heterogeneity of clinical presentations, ~70% of individuals seeking a diagnosis remain undiagnosed. Deep learning has demonstrated...

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Bibliographic Details
Main Authors: Emily Alsentzer, Michelle M. Li, Shilpa N. Kobren, Ayush Noori, Undiagnosed Diseases Network, Isaac S. Kohane, Marinka Zitnik
Format: Article
Language:English
Published: Nature Portfolio 2025-06-01
Series:npj Digital Medicine
Online Access:https://doi.org/10.1038/s41746-025-01749-1
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