Pristimerin Promotes Ubiquitination of HSPA8 and Activates the VAV1/ERK Pathway to Suppress TNBC Proliferation

Pristimerin Promotes Ubiquitination of HSPA8 and Activates the VAV1/ERK Pathway to Suppress TNBC Proliferation

Abstract Triple‐negative breast cancer (TNBC) is a subtype of breast cancer with a poor prognosis. The natural compound pristimerin has shown promising anti‐tumor effect. Here, it is found that pristimerin significantly triggered the activation of autophagy initiation and induced apoptosis in TNBC....

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Main Authors: Qin‐Wen Liu, Qi‐Ling Fan, Jia‐Ying Chen, Jing‐Xin Liu, Yi Li, Qian Luo, Yu‐Peng Chen, Hang‐Tian Wu, An‐Qi Xu, Sheng Wang, Ai‐Ping Lu, Dao‐Gang Guan
Format: Article
Language:English
Published: Wiley 2025-03-01
Series:Advanced Science
Subjects:
HSPA8
pristimerin
triple‐negative breast cancer
VAV1/ERK pathway
Online Access:https://doi.org/10.1002/advs.202413174
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