Vaccinia virus modulates the redox environment by inhibiting reactive oxygen and nitrogen species with increased activity of endogenous antioxidant enzymes

Vaccinia virus modulates the redox environment by inhibiting reactive oxygen and nitrogen species with increased activity of endogenous antioxidant enzymes

Abstract The vaccinia virus (VACV) is the most studied and well-characterised member of the Poxviridae family. However, the mechanisms through which it modulates redox homeostasis in host cells remain unclear. Although oxidative stress, which is marked by elevated levels of reactive species, contrib...

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Main Authors: Marília Bueno da Silva Menegatto, Ariane Coelho Ferraz, Rafaela Lameira Souza Lima, Pedro Henrique Guimarães, Oluwashola Samuel Ola-Olu, Pedro Alves Machado-Junior, Wellington Carvalho Malta, Thaís de Fátima Silva Moraes, Frank Silva Bezerra, Breno de Mello Silva, José Carlos de Magalhães, Jordana Grazziela Alves Coelho dos Reis, Flávio Guimarães da Fonseca, Giliane de Souza Trindade, Erna Geessien Kroon, Cintia Lopes de Brito Magalhães
Format: Article
Language:English
Published: Nature Portfolio 2025-08-01
Series:Scientific Reports
Subjects:
Vaccinia virus
Poxviruses
Antioxidant
Redox homeostasis
Online Access:https://doi.org/10.1038/s41598-025-14433-x
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https://doi.org/10.1038/s41598-025-14433-x

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