Effects of low-intensity pulsed focal ultrasound-mediated delivery of endothelial progenitor-derived exosomes in tMCAo stroke

Effects of low-intensity pulsed focal ultrasound-mediated delivery of endothelial progenitor-derived exosomes in tMCAo stroke

IntroductionExosomes from different sources have been used for therapeutic purposes to target stroke and other disorders. However, exosomes from endothelial progenitor cells (EPCs) have not been tested in any stroke model, and in vivo bio-distribution study is lacking. Targeted delivery of IV-admini...

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Main Authors: Ahmet Alptekin, Mohammad B. Khan, Mahrima Parvin, Hasanul Chowdhury, Sawaiz Kashif, Fowzia A. Selina, Anika Bushra, Justin Kelleher, Santu Ghosh, Dylan Williams, Emily Blumling, Roxan Ara, Asamoah Bosomtwi, Joseph A. Frank, Krishnan M. Dhandapani, Ali S. Arbab
Format: Article
Language:English
Published: Frontiers Media S.A. 2025-04-01
Series:Frontiers in Neurology
Subjects:
ischemic stroke
exosomes
low-intensity-pulsed focused ultrasound (LIPFUS)
magnetic resonance imaging (MRI)
single photon emission computed tomography (SPECT)
Online Access:https://www.frontiersin.org/articles/10.3389/fneur.2025.1543133/full
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https://www.frontiersin.org/articles/10.3389/fneur.2025.1543133/full

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