Multifunctional vitamin D-incorporated PLGA scaffold with BMP/VEGF-overexpressed tonsil-derived MSC via CRISPR/Cas9 for bone tissue regeneration

Multifunctional vitamin D-incorporated PLGA scaffold with BMP/VEGF-overexpressed tonsil-derived MSC via CRISPR/Cas9 for bone tissue regeneration

Guiding endogenous regeneration of bone defects using biomaterials and regenerative medicine is considered an optimal strategy. One of the effective therapeutic approaches involves using transgene-expressed stem cells to treat tissue destruction and replace damaged parts. Among the various gene edit...

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Bibliographic Details
Main Authors: So-Yeon Park, Jun-Kyu Lee, Sang-Hyeok Lee, Da-Seul Kim, Ji-Won Jung, Jun Hyuk Kim, Seung-Woon Baek, Seungkwon You, Dong-Youn Hwang, Dong Keun Han
Format: Article
Language:English
Published: Elsevier 2024-10-01
Series:Materials Today Bio
Subjects:
CRISPR Cas9
Vitamin D
PLGA scaffold
BMP2/VEGF-Overexpression
Tonsil-derived MSC
Online Access:http://www.sciencedirect.com/science/article/pii/S2590006424003156
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