SARM1: a key multifaceted component in immunoregulation, inflammation and neurodegeneration

SARM1: a key multifaceted component in immunoregulation, inflammation and neurodegeneration

The downstream signaling pathways of TLR activation involve a family of adaptor proteins, including MYD88, TIRAP, TRIF, TRAM, and SARM1. The first four proteins stimulate inflammatory and antiviral responses, playing crucial roles in innate immunity against various pathogens. In contrast, SARM1 prom...

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Main Authors: Samuel dos Santos Oliveira, João Vinícius Honório da Silva, Raquel de Souza Vieira, Luís Felipe Serra Moreira, Pedro Henrique Araújo Bandeira, Beatriz Leocata Ramos, Marco Antônio Ataíde Silva, Niels Olsen Saraiva Câmara
Format: Article
Language:English
Published: Frontiers Media S.A. 2025-05-01
Series:Frontiers in Immunology
Subjects:
innate immunity
immunometabolism
cell death
immunoregulation
neurodegenerative disease
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2025.1521364/full
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https://www.frontiersin.org/articles/10.3389/fimmu.2025.1521364/full

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