Serological Profile of Anti-<i>Toxoplasma gondii</i> Antibodies in Liver Transplant Recipients
<i>Toxoplasma gondii (T. gondii)</i>, a globally distributed obligatory intracellular opportunistic parasite that has infected one third of the world population, has different transmission routes including via organ transplantation. The liver has emerged as a frequent transplanted organ...
Saved in:
| Main Authors: | , , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
MDPI AG
2025-01-01
|
| Series: | Tropical Medicine and Infectious Disease |
| Subjects: | |
| Online Access: | https://www.mdpi.com/2414-6366/10/1/18 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1832587347500204032 |
|---|---|
| author | Gabriella Beltrame Pintos Francielly Camilla Bazílio Laurindo Pires Nathália Zini Rita Cássia Martins Alves da Silva Francisco Inaldo Mendes Silva Junior Renato Ferreira da Silva Tainara Souza Pinho Luiz Carlos de Mattos Cinara Cássia Brandão |
| author_facet | Gabriella Beltrame Pintos Francielly Camilla Bazílio Laurindo Pires Nathália Zini Rita Cássia Martins Alves da Silva Francisco Inaldo Mendes Silva Junior Renato Ferreira da Silva Tainara Souza Pinho Luiz Carlos de Mattos Cinara Cássia Brandão |
| author_sort | Gabriella Beltrame Pintos |
| collection | DOAJ |
| description | <i>Toxoplasma gondii (T. gondii)</i>, a globally distributed obligatory intracellular opportunistic parasite that has infected one third of the world population, has different transmission routes including via organ transplantation. The liver has emerged as a frequent transplanted organ in which the transmission of <i>T. gondii</i> can occur between seropositive donors and seronegative recipients. Allied with immunosuppressive therapy, the presence of latent infection in recipients elevates the risk of severe toxoplasmosis. The goal of this study was to evaluate the demographic, clinical, epidemiological, and anti-<i>T. gondii</i> antibody profiles in liver transplant recipients. All demographic, clinical, epidemiological, and serological data were obtained from the electronic medical records of liver transplant recipients from the Liver Transplantation Service of the Hospital de Base in São José do Rio Preto, Brazil, from 2008 to 2018. Data from 48 eligible recipients (females: n = 17; males: n = 31) were evaluated. The recipients were grouped according to their <i>T. gondii</i> serological profiles (G1: IgM−/IgG−; G2: IgM−/IgG+; G3: IgM+/IgG+; G4: IgM+/IgG−). The overall mean age was 55.3 (±15.3) years; the age difference between women (42.7 ± 17 years) and men (62.2 ± 10.9 years) was statistically significant (<i>p</i>-value > 0.0001). The percentages of the serological profiles were 20 (n = 41.7%), 26 (n = 54.1%), and 2 (n = 4.2%) for G1, G2, and G3, respectively. No recipient had a serological profile for G4. Hepatosplenomegaly (47.9%), fever (35.4%), encephalopathy (20.8%), and headache (16.7%) were commonly observed symptoms. No statistically significant differences were observed between the serological group and clinical data (<i>p</i>-value = 0.953). The percentages of coinfection by <i>T. gondii</i> with hepatitis A, B, and C were 47.9%, 20.8%, and 12.5%, respectively. About 41.7% of the recipients later died. The data demonstrate that infection by <i>T. gondii</i> is common in liver transplant recipients, and it is not associated with the analyzed demographic, clinical, and epidemiological data. |
| format | Article |
| id | doaj-art-42126865f27c4a5aaf22d8a2aec7b060 |
| institution | Kabale University |
| issn | 2414-6366 |
| language | English |
| publishDate | 2025-01-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Tropical Medicine and Infectious Disease |
| spelling | doaj-art-42126865f27c4a5aaf22d8a2aec7b0602025-01-24T13:51:24ZengMDPI AGTropical Medicine and Infectious Disease2414-63662025-01-011011810.3390/tropicalmed10010018Serological Profile of Anti-<i>Toxoplasma gondii</i> Antibodies in Liver Transplant RecipientsGabriella Beltrame Pintos0Francielly Camilla Bazílio Laurindo Pires1Nathália Zini2Rita Cássia Martins Alves da Silva3Francisco Inaldo Mendes Silva Junior4Renato Ferreira da Silva5Tainara Souza Pinho6Luiz Carlos de Mattos7Cinara Cássia Brandão8Faculdade de Medicina de São José do Rio Preto (FAMERP), Avenida Brigadeiro Faria Lima, 5416, Vila São Pedro, São José do Rio Preto 15090-000, SP, BrazilFaculdade de Medicina de São José do Rio Preto (FAMERP), Avenida Brigadeiro Faria Lima, 5416, Vila São Pedro, São José do Rio Preto 15090-000, SP, BrazilFaculdade de Medicina de São José do Rio Preto (FAMERP), Avenida Brigadeiro Faria Lima, 5416, Vila São Pedro, São José do Rio Preto 15090-000, SP, BrazilFaculdade de Medicina de São José do Rio Preto (FAMERP), Avenida Brigadeiro Faria Lima, 5416, Vila São Pedro, São José do Rio Preto 15090-000, SP, BrazilHospital de Base—Fundação Faculdade Regional de Medicina (HB-FUNFARME), São José do Rio Preto 15090-000, SP, BrazilFaculdade de Medicina de São José do Rio Preto (FAMERP), Avenida Brigadeiro Faria Lima, 5416, Vila São Pedro, São José do Rio Preto 15090-000, SP, BrazilFaculdade de Medicina de São José do Rio Preto (FAMERP), Avenida Brigadeiro Faria Lima, 5416, Vila São Pedro, São José do Rio Preto 15090-000, SP, BrazilFaculdade de Medicina de São José do Rio Preto (FAMERP), Avenida Brigadeiro Faria Lima, 5416, Vila São Pedro, São José do Rio Preto 15090-000, SP, BrazilFaculdade de Medicina de São José do Rio Preto (FAMERP), Avenida Brigadeiro Faria Lima, 5416, Vila São Pedro, São José do Rio Preto 15090-000, SP, Brazil<i>Toxoplasma gondii (T. gondii)</i>, a globally distributed obligatory intracellular opportunistic parasite that has infected one third of the world population, has different transmission routes including via organ transplantation. The liver has emerged as a frequent transplanted organ in which the transmission of <i>T. gondii</i> can occur between seropositive donors and seronegative recipients. Allied with immunosuppressive therapy, the presence of latent infection in recipients elevates the risk of severe toxoplasmosis. The goal of this study was to evaluate the demographic, clinical, epidemiological, and anti-<i>T. gondii</i> antibody profiles in liver transplant recipients. All demographic, clinical, epidemiological, and serological data were obtained from the electronic medical records of liver transplant recipients from the Liver Transplantation Service of the Hospital de Base in São José do Rio Preto, Brazil, from 2008 to 2018. Data from 48 eligible recipients (females: n = 17; males: n = 31) were evaluated. The recipients were grouped according to their <i>T. gondii</i> serological profiles (G1: IgM−/IgG−; G2: IgM−/IgG+; G3: IgM+/IgG+; G4: IgM+/IgG−). The overall mean age was 55.3 (±15.3) years; the age difference between women (42.7 ± 17 years) and men (62.2 ± 10.9 years) was statistically significant (<i>p</i>-value > 0.0001). The percentages of the serological profiles were 20 (n = 41.7%), 26 (n = 54.1%), and 2 (n = 4.2%) for G1, G2, and G3, respectively. No recipient had a serological profile for G4. Hepatosplenomegaly (47.9%), fever (35.4%), encephalopathy (20.8%), and headache (16.7%) were commonly observed symptoms. No statistically significant differences were observed between the serological group and clinical data (<i>p</i>-value = 0.953). The percentages of coinfection by <i>T. gondii</i> with hepatitis A, B, and C were 47.9%, 20.8%, and 12.5%, respectively. About 41.7% of the recipients later died. The data demonstrate that infection by <i>T. gondii</i> is common in liver transplant recipients, and it is not associated with the analyzed demographic, clinical, and epidemiological data.https://www.mdpi.com/2414-6366/10/1/18solid organ transplantationtoxoplasmosistransmission routesscreeningchemoprophylaxis |
| spellingShingle | Gabriella Beltrame Pintos Francielly Camilla Bazílio Laurindo Pires Nathália Zini Rita Cássia Martins Alves da Silva Francisco Inaldo Mendes Silva Junior Renato Ferreira da Silva Tainara Souza Pinho Luiz Carlos de Mattos Cinara Cássia Brandão Serological Profile of Anti-<i>Toxoplasma gondii</i> Antibodies in Liver Transplant Recipients Tropical Medicine and Infectious Disease solid organ transplantation toxoplasmosis transmission routes screening chemoprophylaxis |
| title | Serological Profile of Anti-<i>Toxoplasma gondii</i> Antibodies in Liver Transplant Recipients |
| title_full | Serological Profile of Anti-<i>Toxoplasma gondii</i> Antibodies in Liver Transplant Recipients |
| title_fullStr | Serological Profile of Anti-<i>Toxoplasma gondii</i> Antibodies in Liver Transplant Recipients |
| title_full_unstemmed | Serological Profile of Anti-<i>Toxoplasma gondii</i> Antibodies in Liver Transplant Recipients |
| title_short | Serological Profile of Anti-<i>Toxoplasma gondii</i> Antibodies in Liver Transplant Recipients |
| title_sort | serological profile of anti i toxoplasma gondii i antibodies in liver transplant recipients |
| topic | solid organ transplantation toxoplasmosis transmission routes screening chemoprophylaxis |
| url | https://www.mdpi.com/2414-6366/10/1/18 |
| work_keys_str_mv | AT gabriellabeltramepintos serologicalprofileofantiitoxoplasmagondiiiantibodiesinlivertransplantrecipients AT franciellycamillabaziliolaurindopires serologicalprofileofantiitoxoplasmagondiiiantibodiesinlivertransplantrecipients AT nathaliazini serologicalprofileofantiitoxoplasmagondiiiantibodiesinlivertransplantrecipients AT ritacassiamartinsalvesdasilva serologicalprofileofantiitoxoplasmagondiiiantibodiesinlivertransplantrecipients AT franciscoinaldomendessilvajunior serologicalprofileofantiitoxoplasmagondiiiantibodiesinlivertransplantrecipients AT renatoferreiradasilva serologicalprofileofantiitoxoplasmagondiiiantibodiesinlivertransplantrecipients AT tainarasouzapinho serologicalprofileofantiitoxoplasmagondiiiantibodiesinlivertransplantrecipients AT luizcarlosdemattos serologicalprofileofantiitoxoplasmagondiiiantibodiesinlivertransplantrecipients AT cinaracassiabrandao serologicalprofileofantiitoxoplasmagondiiiantibodiesinlivertransplantrecipients |