Hepatocyte nuclear factor 4-α is necessary for high fat diet-induced pancreatic β-cell mass expansion and metabolic compensations

Hepatocyte nuclear factor 4-α is necessary for high fat diet-induced pancreatic β-cell mass expansion and metabolic compensations

AimsThis study investigates the role of Hepatocyte Nuclear Factor 4α (HNF4α) in the adaptation of pancreatic β-cells to an HFD-induced obesogenic environment, focusing on β cell mass expansion and metabolic adaptations.Main methodsWe utilized an HNF4α knockout (KO) mouse model, with CRE-recombinase...

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Bibliographic Details
Main Authors: Francieli Caroline de Ramos, Robson Barth, Marcos Rizzon Santos, Milena dos Santos Almeida, Sandra Mara Ferreira, Alex Rafacho, Antônio Carlos Boschero, Gustavo Jorge dos Santos
Format: Article
Language:English
Published: Frontiers Media S.A. 2024-12-01
Series:Frontiers in Endocrinology
Subjects:
β-cell replacement
HNF4α
β-cell mass expansion
obesity
β-cell regeneration
Online Access:https://www.frontiersin.org/articles/10.3389/fendo.2024.1511813/full
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https://www.frontiersin.org/articles/10.3389/fendo.2024.1511813/full

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