A Case Report of a Patient with Soaring Clozapine Levels after Developing a Urinary Tract Infection
Clozapine is an antipsychotic medicine used to treat mental illnesses that is resistant to therapy. It can induce dose-dependent adverse effects such as increased susceptibility to infections and hematological irregularities. In this case report, we present a 37-year-old woman with schizoaffective d...
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| Format: | Article |
| Language: | English |
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Wiley
2024-01-01
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| Series: | Case Reports in Psychiatry |
| Online Access: | http://dx.doi.org/10.1155/2024/9147674 |
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| author | Adesh Kumar Agrawal Soumitra Das Lorenzo Abednego B. Adre Nakka Raghuma Sharanya Kaushik Adarsha Adhikari |
| author_facet | Adesh Kumar Agrawal Soumitra Das Lorenzo Abednego B. Adre Nakka Raghuma Sharanya Kaushik Adarsha Adhikari |
| author_sort | Adesh Kumar Agrawal |
| collection | DOAJ |
| description | Clozapine is an antipsychotic medicine used to treat mental illnesses that is resistant to therapy. It can induce dose-dependent adverse effects such as increased susceptibility to infections and hematological irregularities. In this case report, we present a 37-year-old woman with schizoaffective disorder who experienced clozapine side effects following a moderate urinary tract infection (UTI). Her serum clozapine levels and side effects were increased throughout her UTI but resolved once the UTI was managed conservatively. We reviewed clozapine’s pharmacokinetic properties to understand why serum levels rose during infection. While we could not definitely explain the mechanism of elevation, we emphasize the importance of monitoring serum clozapine levels and keeping watchful for adverse effects, as well as heightened scrutiny, evaluation for recent infections, and regular monitoring of patients. |
| format | Article |
| id | doaj-art-41f7549a7cd54c01a61270d34530b3db |
| institution | Kabale University |
| issn | 2090-6838 |
| language | English |
| publishDate | 2024-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Case Reports in Psychiatry |
| spelling | doaj-art-41f7549a7cd54c01a61270d34530b3db2025-02-03T01:32:20ZengWileyCase Reports in Psychiatry2090-68382024-01-01202410.1155/2024/9147674A Case Report of a Patient with Soaring Clozapine Levels after Developing a Urinary Tract InfectionAdesh Kumar Agrawal0Soumitra Das1Lorenzo Abednego B. Adre2Nakka Raghuma3Sharanya Kaushik4Adarsha Adhikari5All India Institute of Medical SciencesDepartment of PsychiatryManila Doctors HospitalGSL Medical College and General HospitalBangalore Medical College and Research InstituteGandaki Medical CollegeClozapine is an antipsychotic medicine used to treat mental illnesses that is resistant to therapy. It can induce dose-dependent adverse effects such as increased susceptibility to infections and hematological irregularities. In this case report, we present a 37-year-old woman with schizoaffective disorder who experienced clozapine side effects following a moderate urinary tract infection (UTI). Her serum clozapine levels and side effects were increased throughout her UTI but resolved once the UTI was managed conservatively. We reviewed clozapine’s pharmacokinetic properties to understand why serum levels rose during infection. While we could not definitely explain the mechanism of elevation, we emphasize the importance of monitoring serum clozapine levels and keeping watchful for adverse effects, as well as heightened scrutiny, evaluation for recent infections, and regular monitoring of patients.http://dx.doi.org/10.1155/2024/9147674 |
| spellingShingle | Adesh Kumar Agrawal Soumitra Das Lorenzo Abednego B. Adre Nakka Raghuma Sharanya Kaushik Adarsha Adhikari A Case Report of a Patient with Soaring Clozapine Levels after Developing a Urinary Tract Infection Case Reports in Psychiatry |
| title | A Case Report of a Patient with Soaring Clozapine Levels after Developing a Urinary Tract Infection |
| title_full | A Case Report of a Patient with Soaring Clozapine Levels after Developing a Urinary Tract Infection |
| title_fullStr | A Case Report of a Patient with Soaring Clozapine Levels after Developing a Urinary Tract Infection |
| title_full_unstemmed | A Case Report of a Patient with Soaring Clozapine Levels after Developing a Urinary Tract Infection |
| title_short | A Case Report of a Patient with Soaring Clozapine Levels after Developing a Urinary Tract Infection |
| title_sort | case report of a patient with soaring clozapine levels after developing a urinary tract infection |
| url | http://dx.doi.org/10.1155/2024/9147674 |
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