Cardiac Involvement in Chronic Kidney Disease: Epidemiology, Pathophysiology, and Complications
There is a complex interaction between the heart and kidneys. Cardiac and renal function are both affected physically, chemically, and biologically. In end-stage renal disease (ESRD) patients, cardiovascular disease is the leading cause of mortality. The pathophysiological mechanisms leading to card...
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| Main Authors: | , , , , , , , |
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| Format: | Article |
| Language: | English |
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Wolters Kluwer Medknow Publications
2024-10-01
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| Series: | Heart Views |
| Subjects: | |
| Online Access: | https://journals.lww.com/10.4103/heartviews.heartviews_118_24 |
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| _version_ | 1850225350355714048 |
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| author | Eleni Tzatzaki Matthaios Didagelos Eleni Karlafti Christina Melexopoulou Dimitrios Tsavdaris Antonios Ziakas Smaragdi Marinaki Haralambos Karvounis |
| author_facet | Eleni Tzatzaki Matthaios Didagelos Eleni Karlafti Christina Melexopoulou Dimitrios Tsavdaris Antonios Ziakas Smaragdi Marinaki Haralambos Karvounis |
| author_sort | Eleni Tzatzaki |
| collection | DOAJ |
| description | There is a complex interaction between the heart and kidneys. Cardiac and renal function are both affected physically, chemically, and biologically. In end-stage renal disease (ESRD) patients, cardiovascular disease is the leading cause of mortality. The pathophysiological mechanisms leading to cardiac manifestations in end-stage chronic kidney disease are the decreased oxygen supply to the myocardium, the increased preload, and the left ventricular (LV) afterload alterations. The cardiac complications observed in these patients are LV hypertrophy, myocardial fibrosis, diastolic dysfunction of the left ventricle, coronary artery disease, calcification of the mitral annulus and the aortic valve, and pulmonary hypertension. Several biomarkers that may lead to prevention and early identification of heart complications in these patients are being investigated. In conclusion, the complex relationship between cardiac and renal functions significantly affects patient outcomes in ESRD, highlighting the urgent need for early recognition and intervention strategies to limit cardiovascular complications and improve overall patient care. |
| format | Article |
| id | doaj-art-41d631baf3d849deb8d0b05fbe2e7ea2 |
| institution | OA Journals |
| issn | 1995-705X 0976-5123 |
| language | English |
| publishDate | 2024-10-01 |
| publisher | Wolters Kluwer Medknow Publications |
| record_format | Article |
| series | Heart Views |
| spelling | doaj-art-41d631baf3d849deb8d0b05fbe2e7ea22025-08-20T02:05:23ZengWolters Kluwer Medknow PublicationsHeart Views1995-705X0976-51232024-10-0125424925410.4103/heartviews.heartviews_118_24Cardiac Involvement in Chronic Kidney Disease: Epidemiology, Pathophysiology, and ComplicationsEleni TzatzakiMatthaios DidagelosEleni KarlaftiChristina MelexopoulouDimitrios TsavdarisAntonios ZiakasSmaragdi MarinakiHaralambos KarvounisThere is a complex interaction between the heart and kidneys. Cardiac and renal function are both affected physically, chemically, and biologically. In end-stage renal disease (ESRD) patients, cardiovascular disease is the leading cause of mortality. The pathophysiological mechanisms leading to cardiac manifestations in end-stage chronic kidney disease are the decreased oxygen supply to the myocardium, the increased preload, and the left ventricular (LV) afterload alterations. The cardiac complications observed in these patients are LV hypertrophy, myocardial fibrosis, diastolic dysfunction of the left ventricle, coronary artery disease, calcification of the mitral annulus and the aortic valve, and pulmonary hypertension. Several biomarkers that may lead to prevention and early identification of heart complications in these patients are being investigated. In conclusion, the complex relationship between cardiac and renal functions significantly affects patient outcomes in ESRD, highlighting the urgent need for early recognition and intervention strategies to limit cardiovascular complications and improve overall patient care.https://journals.lww.com/10.4103/heartviews.heartviews_118_24cardiacfailureheartkidneyrenal |
| spellingShingle | Eleni Tzatzaki Matthaios Didagelos Eleni Karlafti Christina Melexopoulou Dimitrios Tsavdaris Antonios Ziakas Smaragdi Marinaki Haralambos Karvounis Cardiac Involvement in Chronic Kidney Disease: Epidemiology, Pathophysiology, and Complications Heart Views cardiac failure heart kidney renal |
| title | Cardiac Involvement in Chronic Kidney Disease: Epidemiology, Pathophysiology, and Complications |
| title_full | Cardiac Involvement in Chronic Kidney Disease: Epidemiology, Pathophysiology, and Complications |
| title_fullStr | Cardiac Involvement in Chronic Kidney Disease: Epidemiology, Pathophysiology, and Complications |
| title_full_unstemmed | Cardiac Involvement in Chronic Kidney Disease: Epidemiology, Pathophysiology, and Complications |
| title_short | Cardiac Involvement in Chronic Kidney Disease: Epidemiology, Pathophysiology, and Complications |
| title_sort | cardiac involvement in chronic kidney disease epidemiology pathophysiology and complications |
| topic | cardiac failure heart kidney renal |
| url | https://journals.lww.com/10.4103/heartviews.heartviews_118_24 |
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