Enhancing the utility of polygenic scores in Alzheimer’s disease through systematic curation and annotation

Enhancing the utility of polygenic scores in Alzheimer’s disease through systematic curation and annotation

IntroductionPolygenic Scores (PGSs) assess cumulative genetic risk variants that contribute to the association with complex diseases like Alzheimer’s Disease (AD). The PGS Catalog is a valuable repository of PGSs of various complex diseases, but it lacks standardized annotations and harmonization, m...

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Bibliographic Details
Main Authors:	Savannah Mwesigwa, Yulin Dai, Nitesh Enduru, Zhongming Zhao
Format:	Article
Language:	English
Published:	Frontiers Media S.A. 2025-02-01
Series:	Frontiers in Genetics
Subjects:	Alzheimer’s disease genetic variant PGS catalog polygenic scores rank aggregation
Online Access:	https://www.frontiersin.org/articles/10.3389/fgene.2025.1507395/full
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