Therapeutic efficacy of a potent anti-Venezuelan equine encephalitis virus antibody is contingent on Fc effector function

Therapeutic efficacy of a potent anti-Venezuelan equine encephalitis virus antibody is contingent on Fc effector function

The development of specific, safe, and potent monoclonal antibodies (Abs) has led to novel therapeutic options for infectious disease. In addition to preventing viral infection through neutralization, Abs can clear infected cells and induce immunomodulatory functions through engagement of their crys...

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Bibliographic Details
Main Authors: Jennifer L. Schwedler, Maxwell A. Stefan, Christine E. Thatcher, Peter R. McIlroy, Anupama Sinha, Ashlee M. Phillips, Christopher A. Sumner, Colleen M. Courtney, Christina Y. Kim, Dina R. Weilhammer, Brooke Harmon
Format: Article
Language:English
Published: Taylor & Francis Group 2024-12-01
Series:mAbs
Subjects:
Antibody dependent cell-mediated cytotoxicity (ADCC)
antibody therapy
complement
complement dependent cytotoxicity (CDC)
Fc effector function
Fc-engineering
Online Access:https://www.tandfonline.com/doi/10.1080/19420862.2023.2297451
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https://www.tandfonline.com/doi/10.1080/19420862.2023.2297451

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