Toxic Epidermal Necrolysis Associated with Antiepileptic Drugs and Cranial Radiation Therapy
Case reports on the development of toxic epidermal necrolysis (TEN) associated with concurrent administration of phenytoin with cranial radiation therapy (Ahmed (2004), Criton et al. (1997), and Rzany et al. (1996)), but reports about erythema multiforme, which can develop in patients treated with l...
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| Format: | Article |
| Language: | English |
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Wiley
2013-01-01
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| Series: | Case Reports in Oncological Medicine |
| Online Access: | http://dx.doi.org/10.1155/2013/415031 |
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| author | Shereen Elazzazy Taghrid Abu Hassan Ashraf El Seid Cicy Mary Jacob |
| author_facet | Shereen Elazzazy Taghrid Abu Hassan Ashraf El Seid Cicy Mary Jacob |
| author_sort | Shereen Elazzazy |
| collection | DOAJ |
| description | Case reports on the development of toxic epidermal necrolysis (TEN) associated with concurrent administration of phenytoin with cranial radiation therapy (Ahmed (2004), Criton et al. (1997), and Rzany et al. (1996)), but reports about erythema multiforme, which can develop in patients treated with levetiracetam and cranial irradiation, are very limited. This paper presents evidence that TEN may be induced by concurrent use of radiation with both phenytoin and levetiracetam. Our case is a 42-year-old male patient, a case of gliosarcoma who developed purpuric dermatitis associated with phenytoin when combined with cranial radiation therapy; although phenytoin was discontinued and switched to levetiracetam, the patient had more severe symptoms of toxic epidermal necrolysis (TEN) on levetiracetam; the patient improved with aggressive symptom management, discontinuation of antiepileptic drugs (AEDs), and holding radiotherapy. Although TEN is a rare toxicity, physicians should pay a special attention to the monitoring of brain tumor patients on antiepileptic prophylaxis during cranial irradiation; furthermore, patients should be counselled to notify their physicians if they develop any new or unusual symptoms. |
| format | Article |
| id | doaj-art-41b49b2a079842e88bbef670b053866a |
| institution | Kabale University |
| issn | 2090-6706 2090-6714 |
| language | English |
| publishDate | 2013-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Case Reports in Oncological Medicine |
| spelling | doaj-art-41b49b2a079842e88bbef670b053866a2025-02-03T01:28:39ZengWileyCase Reports in Oncological Medicine2090-67062090-67142013-01-01201310.1155/2013/415031415031Toxic Epidermal Necrolysis Associated with Antiepileptic Drugs and Cranial Radiation TherapyShereen Elazzazy0Taghrid Abu Hassan1Ashraf El Seid2Cicy Mary Jacob3Pharmacy Department, National Center for Cancer Care and Research NCCCR, Hamad Medical Corporation, Doha, QatarPharmacy Department, National Center for Cancer Care and Research NCCCR, Hamad Medical Corporation, Doha, QatarOncology Hematology Department, National Center for Cancer Care and Research NCCCR, Hamad Medical Corporation, Doha, QatarOncology Hematology Department, National Center for Cancer Care and Research NCCCR, Hamad Medical Corporation, Doha, QatarCase reports on the development of toxic epidermal necrolysis (TEN) associated with concurrent administration of phenytoin with cranial radiation therapy (Ahmed (2004), Criton et al. (1997), and Rzany et al. (1996)), but reports about erythema multiforme, which can develop in patients treated with levetiracetam and cranial irradiation, are very limited. This paper presents evidence that TEN may be induced by concurrent use of radiation with both phenytoin and levetiracetam. Our case is a 42-year-old male patient, a case of gliosarcoma who developed purpuric dermatitis associated with phenytoin when combined with cranial radiation therapy; although phenytoin was discontinued and switched to levetiracetam, the patient had more severe symptoms of toxic epidermal necrolysis (TEN) on levetiracetam; the patient improved with aggressive symptom management, discontinuation of antiepileptic drugs (AEDs), and holding radiotherapy. Although TEN is a rare toxicity, physicians should pay a special attention to the monitoring of brain tumor patients on antiepileptic prophylaxis during cranial irradiation; furthermore, patients should be counselled to notify their physicians if they develop any new or unusual symptoms.http://dx.doi.org/10.1155/2013/415031 |
| spellingShingle | Shereen Elazzazy Taghrid Abu Hassan Ashraf El Seid Cicy Mary Jacob Toxic Epidermal Necrolysis Associated with Antiepileptic Drugs and Cranial Radiation Therapy Case Reports in Oncological Medicine |
| title | Toxic Epidermal Necrolysis Associated with Antiepileptic Drugs and Cranial Radiation Therapy |
| title_full | Toxic Epidermal Necrolysis Associated with Antiepileptic Drugs and Cranial Radiation Therapy |
| title_fullStr | Toxic Epidermal Necrolysis Associated with Antiepileptic Drugs and Cranial Radiation Therapy |
| title_full_unstemmed | Toxic Epidermal Necrolysis Associated with Antiepileptic Drugs and Cranial Radiation Therapy |
| title_short | Toxic Epidermal Necrolysis Associated with Antiepileptic Drugs and Cranial Radiation Therapy |
| title_sort | toxic epidermal necrolysis associated with antiepileptic drugs and cranial radiation therapy |
| url | http://dx.doi.org/10.1155/2013/415031 |
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