4-1BBL enhances CD8+ T cell responses induced by vectored vaccines in mice but fails to improve immunogenicity in rhesus macaques.

4-1BBL enhances CD8+ T cell responses induced by vectored vaccines in mice but fails to improve immunogenicity in rhesus macaques.

T cells play a central role in the immune response to many of the world's major infectious diseases. In this study we investigated the tumour necrosis factor receptor superfamily costimulatory molecule, 4-1BBL (CD137L, TNFSF9), for its ability to increase T cell immunogenicity induced by a vari...

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Bibliographic Details
Main Authors: Alexandra J Spencer, Julie Furze, Jared D Honeycutt, Alice Calvert, Saroj Saurya, Stefano Colloca, David H Wyllie, Sarah C Gilbert, Migena Bregu, Matthew G Cottingham, Adrian V S Hill
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2014-01-01
Series:PLoS ONE
Online Access:https://doi.org/10.1371/journal.pone.0105520
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https://doi.org/10.1371/journal.pone.0105520

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