Omeprazole: Inhibiting the Final Common Pathway to Acid Secretion - The Acid Pump
Omeprazole is the first agent in a new therapeutic advance class the proton or acid pump inhibitors which represents a significant therapeutic advance in the treatment of acid related diseases. Omeprazole reduces gastric acid secretion at its source – the acid pump of the parietal cell, thereby offe...
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| Main Author: | |
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| Format: | Article |
| Language: | English |
| Published: |
Wiley
1989-01-01
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| Series: | Canadian Journal of Gastroenterology |
| Online Access: | http://dx.doi.org/10.1155/1989/463572 |
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| Summary: | Omeprazole is the first agent in a new therapeutic advance class
the proton or acid pump inhibitors which represents a significant therapeutic
advance in the treatment of acid related diseases. Omeprazole reduces gastric
acid secretion at its source – the acid pump of the parietal cell, thereby offering
precise and consistent clinical effects. Omeprazole once daily has been shown to
heal over 80% of duodenal ulcers within two weeks and over 95% within four weeks
In gastric ulcer, the healing rates are up to 80% within four weeks and 96% within
eight weeks. More patients are free from symptoms earlier on omeprazole therapy
than with the H2 receptor antagonists. Omeprazole is also effective in healing and
symptom relief even where prolonged H2 receptor antagonist therapy has been
unsuccessful. Omeprnzole has been shown in clinical trials to be the first consistently
effective treatment of erosive/ulcerative reflux esophagitis. Complete healing
is achieved in the majority of patients and symptom relief is rapid. In clinical
trials with 20 mg once daily, over 70% of patients healed within four weeks and up
to 85% healed within eight weeks. Also. patients with erosive/ulcerative reflux
esophagitis resistant to three months or more of treatment with full therapeutic
doses of H2 receptor antagonists have shown significant benefit, with healing
rates of 49% within four weeks and 73% within eight weeks of therapy with
omcprazole. The rare Zollinger-Ellison syndrome has been difficult to treat in the
past due to the massive hypersecretion of gastric acid Omeprazole has proved
highly effective in this syndrome, being well tolerated by patients who have received
more than five years of continuous treatment with daily oral doses up to 160 mg. In
summary, in extensive clinical trials omeprazole has been shown to be highly
effective in the treatment of duodenal and gastric ulcers, erosive/ulcerative reflux
esophagitis and Zollinger-Ellison syndrome. Omeprazole is well tolerated and is
without any established side effects when used for short periods. It remains to be
established whether H2 blockers still represent the best available therapy for acute
treatment of peptic disorders, and whether maintenance therapy is best achieved
with H2 blockers or with proton pump blockers. |
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| ISSN: | 0835-7900 |