State-dependent inter-network functional connectivity development in neonatal brain from the developing human connectome project
Although recent studies have consistently reported the emergence of resting-state networks in early infancy, the changes in inter-network functional connectivity with age are controversial and the alterations in its dynamics remain unclear at this stage. This study aimed to investigate dynamic funct...
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| Format: | Article |
| Language: | English |
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Elsevier
2025-01-01
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| Series: | Developmental Cognitive Neuroscience |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S1878929324001579 |
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| author | Zhiyong Zhao Ruolin Li Yihan Wu Mingyang Li Dan Wu |
| author_facet | Zhiyong Zhao Ruolin Li Yihan Wu Mingyang Li Dan Wu |
| author_sort | Zhiyong Zhao |
| collection | DOAJ |
| description | Although recent studies have consistently reported the emergence of resting-state networks in early infancy, the changes in inter-network functional connectivity with age are controversial and the alterations in its dynamics remain unclear at this stage. This study aimed to investigate dynamic functional network connectivity (dFNC) using resting-state functional MRI in 244 full-term (age: 37–44 weeks) and 36 preterm infants (age: 37–43 weeks) from the dHCP dataset. We evaluated whether early dFNC exhibits age-dependent changes and is influenced by preterm birth. Gestational age (GA) and postnatal age (PNA) showed different effects on variance of FNC change over time during fMRI scan in resting-state networks, especially among high-order association networks. These variances were significantly reduced by preterm birth. Moreover, two states of weakly-connected (State Ⅰ) and strongly-connected (State Ⅱ) FNC were identified. The fraction window and dwell time in State Ⅰ, and the transition from State Ⅱ to State Ⅰ, all showed significantly negative correlations with both GA and PNA. Preterm-born infants spent a longer time in the weakly-connected state compared to term-born infants. These findings suggest a state-dependent development of dynamic FNC across brain networks in the early stages, gradually reconfiguring towards a more flexible and dynamic system with stronger connections. |
| format | Article |
| id | doaj-art-4161e36a1ad24dea828f54fad5c1da8c |
| institution | Kabale University |
| issn | 1878-9293 |
| language | English |
| publishDate | 2025-01-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Developmental Cognitive Neuroscience |
| spelling | doaj-art-4161e36a1ad24dea828f54fad5c1da8c2025-01-22T05:41:19ZengElsevierDevelopmental Cognitive Neuroscience1878-92932025-01-0171101496State-dependent inter-network functional connectivity development in neonatal brain from the developing human connectome projectZhiyong Zhao0Ruolin Li1Yihan Wu2Mingyang Li3Dan Wu4Department of Radiology, Children’s Hospital, Zhejiang University School of Medicine, National Clinical Research Center for Child Health, Hangzhou, ChinaDepartment of Radiology, Children’s Hospital of Philadelphia, Philadelphia, USADepartment of Biomedical Engineering, Johns Hopkins University, USAKey Laboratory for Biomedical Engineering of Ministry of Education, Department of Biomedical Engineering, College of Biomedical Engineering & Instrument Science, Zhejiang University, Hangzhou, ChinaKey Laboratory for Biomedical Engineering of Ministry of Education, Department of Biomedical Engineering, College of Biomedical Engineering & Instrument Science, Zhejiang University, Hangzhou, China; Correspondence to: Key Laboratory for Biomedical Engineering of Ministry of Education, Department of Biomedical Engineering, College of Biomedical Engineering & Instrument Science, Zhejiang University, Room 525, Zhou Yiqing Building, Yuquan Campus, Hangzhou 310027, China.Although recent studies have consistently reported the emergence of resting-state networks in early infancy, the changes in inter-network functional connectivity with age are controversial and the alterations in its dynamics remain unclear at this stage. This study aimed to investigate dynamic functional network connectivity (dFNC) using resting-state functional MRI in 244 full-term (age: 37–44 weeks) and 36 preterm infants (age: 37–43 weeks) from the dHCP dataset. We evaluated whether early dFNC exhibits age-dependent changes and is influenced by preterm birth. Gestational age (GA) and postnatal age (PNA) showed different effects on variance of FNC change over time during fMRI scan in resting-state networks, especially among high-order association networks. These variances were significantly reduced by preterm birth. Moreover, two states of weakly-connected (State Ⅰ) and strongly-connected (State Ⅱ) FNC were identified. The fraction window and dwell time in State Ⅰ, and the transition from State Ⅱ to State Ⅰ, all showed significantly negative correlations with both GA and PNA. Preterm-born infants spent a longer time in the weakly-connected state compared to term-born infants. These findings suggest a state-dependent development of dynamic FNC across brain networks in the early stages, gradually reconfiguring towards a more flexible and dynamic system with stronger connections.http://www.sciencedirect.com/science/article/pii/S1878929324001579NeonateResting-state networkDynamic functional connectivityState-dependentPretermDHCP |
| spellingShingle | Zhiyong Zhao Ruolin Li Yihan Wu Mingyang Li Dan Wu State-dependent inter-network functional connectivity development in neonatal brain from the developing human connectome project Developmental Cognitive Neuroscience Neonate Resting-state network Dynamic functional connectivity State-dependent Preterm DHCP |
| title | State-dependent inter-network functional connectivity development in neonatal brain from the developing human connectome project |
| title_full | State-dependent inter-network functional connectivity development in neonatal brain from the developing human connectome project |
| title_fullStr | State-dependent inter-network functional connectivity development in neonatal brain from the developing human connectome project |
| title_full_unstemmed | State-dependent inter-network functional connectivity development in neonatal brain from the developing human connectome project |
| title_short | State-dependent inter-network functional connectivity development in neonatal brain from the developing human connectome project |
| title_sort | state dependent inter network functional connectivity development in neonatal brain from the developing human connectome project |
| topic | Neonate Resting-state network Dynamic functional connectivity State-dependent Preterm DHCP |
| url | http://www.sciencedirect.com/science/article/pii/S1878929324001579 |
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