Association of Lipids with Oxidative Stress Biomarkers in Subclinical Hypothyroidism
Objective. The aim of the present study was to evaluate the oxidative stress biomarkers in patients with subclinical hypothyroidism (n=20) and health controls (n=20). Subjects and Methods. Total cholesterol (TC), triglycerides (TGs), low-density lipoprotein-cholesterol (LDL-C), high-density lipoprot...
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| Format: | Article |
| Language: | English |
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Wiley
2012-01-01
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| Series: | International Journal of Endocrinology |
| Online Access: | http://dx.doi.org/10.1155/2012/856359 |
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| author | Adriana Santi Marta M. M. F. Duarte Charlene C. de Menezes Vania Lucia Loro |
| author_facet | Adriana Santi Marta M. M. F. Duarte Charlene C. de Menezes Vania Lucia Loro |
| author_sort | Adriana Santi |
| collection | DOAJ |
| description | Objective. The aim of the present study was to evaluate the oxidative stress biomarkers in patients with subclinical hypothyroidism (n=20) and health controls (n=20). Subjects and Methods. Total cholesterol (TC), triglycerides (TGs), low-density lipoprotein-cholesterol (LDL-C), high-density lipoprotein cholesterol (HDL-C), thiobarbituric acid reactive substances (TBARSs), catalase (CAT), superoxide dismutase (SOD), and arylesterase (ARE) were analyzed. Results. TC, LDL-C, TBARS, and CAT were higher in subclinical hypothyroidism patients, whereas SOD did not change. Arylesterase activity was significantly lower in the SH group, compared with the control group. Correlation analyses revealed the association of lipids (TC and LDL-C) with both oxidative stress biomarkers and thyrotropin (TSH). Thyroid hormones were correlated only with triglyceride levels. In addition, TSH was significantly correlated with TBARS, CAT, and SOD. However, no significant correlations were observed after controlling TC levels. Conclusions. We found that SH patients are under increased oxidative stress manifested by reduced ARE activity and elevated lipoperoxidation and CAT activity. Secondary hypercholesterolemia to thyroid dysfunction and not hypothyroidism per se appears to be associated with oxidative stress in subclinical hypothyroidism. |
| format | Article |
| id | doaj-art-4147ebf5bee34ba7877c55587bf48b86 |
| institution | Kabale University |
| issn | 1687-8337 1687-8345 |
| language | English |
| publishDate | 2012-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | International Journal of Endocrinology |
| spelling | doaj-art-4147ebf5bee34ba7877c55587bf48b862025-02-03T01:29:15ZengWileyInternational Journal of Endocrinology1687-83371687-83452012-01-01201210.1155/2012/856359856359Association of Lipids with Oxidative Stress Biomarkers in Subclinical HypothyroidismAdriana Santi0Marta M. M. F. Duarte1Charlene C. de Menezes2Vania Lucia Loro3Programa de Pós-Graduação em Bioquímica Toxicológica, Departamento de Química, Centro de Ciências Naturais e Exatas, Universidade Federal de Santa Maria, 97105-900 Santa Maria, RS, BrazilPrograma de Pós-Graduação em Bioquímica Toxicológica, Departamento de Química, Centro de Ciências Naturais e Exatas, Universidade Federal de Santa Maria, 97105-900 Santa Maria, RS, BrazilPrograma de Pós-Graduação em Bioquímica Toxicológica, Departamento de Química, Centro de Ciências Naturais e Exatas, Universidade Federal de Santa Maria, 97105-900 Santa Maria, RS, BrazilPrograma de Pós-Graduação em Bioquímica Toxicológica, Departamento de Química, Centro de Ciências Naturais e Exatas, Universidade Federal de Santa Maria, 97105-900 Santa Maria, RS, BrazilObjective. The aim of the present study was to evaluate the oxidative stress biomarkers in patients with subclinical hypothyroidism (n=20) and health controls (n=20). Subjects and Methods. Total cholesterol (TC), triglycerides (TGs), low-density lipoprotein-cholesterol (LDL-C), high-density lipoprotein cholesterol (HDL-C), thiobarbituric acid reactive substances (TBARSs), catalase (CAT), superoxide dismutase (SOD), and arylesterase (ARE) were analyzed. Results. TC, LDL-C, TBARS, and CAT were higher in subclinical hypothyroidism patients, whereas SOD did not change. Arylesterase activity was significantly lower in the SH group, compared with the control group. Correlation analyses revealed the association of lipids (TC and LDL-C) with both oxidative stress biomarkers and thyrotropin (TSH). Thyroid hormones were correlated only with triglyceride levels. In addition, TSH was significantly correlated with TBARS, CAT, and SOD. However, no significant correlations were observed after controlling TC levels. Conclusions. We found that SH patients are under increased oxidative stress manifested by reduced ARE activity and elevated lipoperoxidation and CAT activity. Secondary hypercholesterolemia to thyroid dysfunction and not hypothyroidism per se appears to be associated with oxidative stress in subclinical hypothyroidism.http://dx.doi.org/10.1155/2012/856359 |
| spellingShingle | Adriana Santi Marta M. M. F. Duarte Charlene C. de Menezes Vania Lucia Loro Association of Lipids with Oxidative Stress Biomarkers in Subclinical Hypothyroidism International Journal of Endocrinology |
| title | Association of Lipids with Oxidative Stress Biomarkers in Subclinical Hypothyroidism |
| title_full | Association of Lipids with Oxidative Stress Biomarkers in Subclinical Hypothyroidism |
| title_fullStr | Association of Lipids with Oxidative Stress Biomarkers in Subclinical Hypothyroidism |
| title_full_unstemmed | Association of Lipids with Oxidative Stress Biomarkers in Subclinical Hypothyroidism |
| title_short | Association of Lipids with Oxidative Stress Biomarkers in Subclinical Hypothyroidism |
| title_sort | association of lipids with oxidative stress biomarkers in subclinical hypothyroidism |
| url | http://dx.doi.org/10.1155/2012/856359 |
| work_keys_str_mv | AT adrianasanti associationoflipidswithoxidativestressbiomarkersinsubclinicalhypothyroidism AT martammfduarte associationoflipidswithoxidativestressbiomarkersinsubclinicalhypothyroidism AT charlenecdemenezes associationoflipidswithoxidativestressbiomarkersinsubclinicalhypothyroidism AT vanialucialoro associationoflipidswithoxidativestressbiomarkersinsubclinicalhypothyroidism |