Cancer Stem Cells and Their Microenvironment: Biology and Therapeutic Implications
Tumor consists of heterogeneous cancer cells including cancer stem cells (CSCs) that can terminally differentiate into tumor bulk. Normal stem cells in normal organs regulate self-renewal within a stem cell niche. Likewise, accumulating evidence has also suggested that CSCs are maintained extrinsica...
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| Format: | Article |
| Language: | English |
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Wiley
2017-01-01
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| Series: | Stem Cells International |
| Online Access: | http://dx.doi.org/10.1155/2017/3714190 |
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| _version_ | 1832549990635929600 |
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| author | Eunice Yuen-Ting Lau Nicole Pui-Yu Ho Terence Kin-Wah Lee |
| author_facet | Eunice Yuen-Ting Lau Nicole Pui-Yu Ho Terence Kin-Wah Lee |
| author_sort | Eunice Yuen-Ting Lau |
| collection | DOAJ |
| description | Tumor consists of heterogeneous cancer cells including cancer stem cells (CSCs) that can terminally differentiate into tumor bulk. Normal stem cells in normal organs regulate self-renewal within a stem cell niche. Likewise, accumulating evidence has also suggested that CSCs are maintained extrinsically within the tumor microenvironment, which includes both cellular and physical factors. Here, we review the significance of stromal cells, immune cells, extracellular matrix, tumor stiffness, and hypoxia in regulation of CSC plasticity and therapeutic resistance. With a better understanding of how CSC interacts with its niche, we are able to identify potential therapeutic targets for the development of more effective treatments against cancer. |
| format | Article |
| id | doaj-art-4131a94a57cd4eb4a85b1d320ba2d53f |
| institution | Kabale University |
| issn | 1687-966X 1687-9678 |
| language | English |
| publishDate | 2017-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Stem Cells International |
| spelling | doaj-art-4131a94a57cd4eb4a85b1d320ba2d53f2025-02-03T06:08:00ZengWileyStem Cells International1687-966X1687-96782017-01-01201710.1155/2017/37141903714190Cancer Stem Cells and Their Microenvironment: Biology and Therapeutic ImplicationsEunice Yuen-Ting Lau0Nicole Pui-Yu Ho1Terence Kin-Wah Lee2Department of Applied Biology and Chemical Technology, The Hong Kong Polytechnic University, Kowloon, Hong KongDepartment of Applied Biology and Chemical Technology, The Hong Kong Polytechnic University, Kowloon, Hong KongDepartment of Applied Biology and Chemical Technology, The Hong Kong Polytechnic University, Kowloon, Hong KongTumor consists of heterogeneous cancer cells including cancer stem cells (CSCs) that can terminally differentiate into tumor bulk. Normal stem cells in normal organs regulate self-renewal within a stem cell niche. Likewise, accumulating evidence has also suggested that CSCs are maintained extrinsically within the tumor microenvironment, which includes both cellular and physical factors. Here, we review the significance of stromal cells, immune cells, extracellular matrix, tumor stiffness, and hypoxia in regulation of CSC plasticity and therapeutic resistance. With a better understanding of how CSC interacts with its niche, we are able to identify potential therapeutic targets for the development of more effective treatments against cancer.http://dx.doi.org/10.1155/2017/3714190 |
| spellingShingle | Eunice Yuen-Ting Lau Nicole Pui-Yu Ho Terence Kin-Wah Lee Cancer Stem Cells and Their Microenvironment: Biology and Therapeutic Implications Stem Cells International |
| title | Cancer Stem Cells and Their Microenvironment: Biology and Therapeutic Implications |
| title_full | Cancer Stem Cells and Their Microenvironment: Biology and Therapeutic Implications |
| title_fullStr | Cancer Stem Cells and Their Microenvironment: Biology and Therapeutic Implications |
| title_full_unstemmed | Cancer Stem Cells and Their Microenvironment: Biology and Therapeutic Implications |
| title_short | Cancer Stem Cells and Their Microenvironment: Biology and Therapeutic Implications |
| title_sort | cancer stem cells and their microenvironment biology and therapeutic implications |
| url | http://dx.doi.org/10.1155/2017/3714190 |
| work_keys_str_mv | AT euniceyuentinglau cancerstemcellsandtheirmicroenvironmentbiologyandtherapeuticimplications AT nicolepuiyuho cancerstemcellsandtheirmicroenvironmentbiologyandtherapeuticimplications AT terencekinwahlee cancerstemcellsandtheirmicroenvironmentbiologyandtherapeuticimplications |