A cGAMP‐Containing Hydrogel for Prolonged SARS‐CoV‐2 Receptor‐Binding Domain Subunit Vaccine Exposure Induces a Broad and Potent Humoral Response

A cGAMP‐Containing Hydrogel for Prolonged SARS‐CoV‐2 Receptor‐Binding Domain Subunit Vaccine Exposure Induces a Broad and Potent Humoral Response

The receptor‐binding domain (RBD) of the SARS‐CoV‐2 virus spike protein has emerged as a promising target for the generation of neutralizing antibodies. Although the RBD subunit is more stable than its encoding mRNA, RBD is poorly immunogenic. It is hypothesized that this limitation can be overcome...

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Bibliographic Details
Main Authors: Volker Böhnert, Emily C. Gale, Lauren J. Lahey, Jerry Yan, Abigail E. Powell, Ben S. Ou, Jacqueline A. Carozza, Lingyin Li, Eric A. Appel
Format: Article
Language:English
Published: Wiley-VCH 2025-01-01
Series:Advanced NanoBiomed Research
Subjects:
COVID‐19
drug delivery
SARS‐CoV‐2
stimulators of interferon genes
vaccines
Online Access:https://doi.org/10.1002/anbr.202400077
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https://doi.org/10.1002/anbr.202400077

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