Autoantibodies immuno-mechanically modulate platelet contractile force and bleeding risk

Autoantibodies immuno-mechanically modulate platelet contractile force and bleeding risk

Abstract Altered mechanotransduction has been proposed as a putative mechanism for disease pathophysiology, yet evidence remains scarce. Here we introduce a concept we call single cell immuno-mechanical modulation, which links immunology, integrin biology, cellular mechanics, and disease pathophysio...

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Main Authors: Oluwamayokun Oshinowo, Renee Copeland, Anamika Patel, Nina Shaver, Meredith E. Fay, Rebecca Jeltuhin, Yijin Xiang, Christina Caruso, Adiya E. Otumala, Sarah Hernandez, Priscilla Delgado, Gabrielle Dean, James M. Kelvin, Daniel Chester, Ashley C. Brown, Erik C. Dreaden, Traci Leong, Jesse Waggoner, Renhao Li, Eric Ortlund, Carolyn Bennett, Wilbur A. Lam, David R. Myers
Format: Article
Language:English
Published: Nature Portfolio 2024-11-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-024-54309-8
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