M2 macrophages activate the IL-10/JAK2/STAT3 pathway to induce pathological microangiogenesis in the nucleus pulposus exacerbating intervertebral disc degeneration

M2 macrophages activate the IL-10/JAK2/STAT3 pathway to induce pathological microangiogenesis in the nucleus pulposus exacerbating intervertebral disc degeneration

Abstract Background Macrophage infiltration accompanied by pathological microangiogenesis in the nucleus pulposus (NP) plays a critical role in the progression of intervertebral disc degeneration (IDD). However, the involvement of M2 macrophages in mediating NP pathological angiogenesis and their un...

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Bibliographic Details
Main Authors: Si-ping Zhang, Min Tong, Jun Mo, Zhen-Yu Dong, Yi-Fei Huang
Format: Article
Language:English
Published: BMC 2025-05-01
Series:Journal of Orthopaedic Surgery and Research
Subjects:
Intervertebral disc degeneration
Macrophage
Microangiogenesis
Nucleus pulposus
Online Access:https://doi.org/10.1186/s13018-025-05962-2
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https://doi.org/10.1186/s13018-025-05962-2

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