TNFα Receptor 1 and Not Receptor 2 Affect Annulus Fibrosus and Nucleus Pulposus Response to Cytokine Challenge in a Rat Model

TNFα Receptor 1 and Not Receptor 2 Affect Annulus Fibrosus and Nucleus Pulposus Response to Cytokine Challenge in a Rat Model

ABSTRACT Background Painful intervertebral disc (IVD) degeneration (IVDD) involves chronic inflammation. Developing translational immunomodulatory strategies for IVDD is a priority with tumor necrosis factor alpha (TNFα) signaling an important target. TNFα binds to 2 receptors (TNFRs), with TNFR1 si...

Full description

Saved in:
Bibliographic Details
Main Authors: Timothy D. Jacobsen, S. Olga Yiantsos, Jennifer Gansau, James Meyers, Damien Laudier, James C. Iatridis
Format: Article
Language:English
Published: Wiley 2025-06-01
Series:JOR Spine
Subjects:
Atsttrin
Cell Culture
ErythrosineB
inflammation
intervertebral disc degeneration
Physcion‐8‐O‐β‐D‐monoglucoside
Online Access:https://doi.org/10.1002/jsp2.70070
Tags: Add Tag
No Tags, Be the first to tag this record!

Internet

https://doi.org/10.1002/jsp2.70070

Similar Items