The GDF11 represses the Stat3 signaling pathway, conferring metabolic, inflammatory, and oncogenic restrictions in cells derived from human hepatocellular carcinoma.

Introduction and Objectives: GDF11 has shown potential in displaying anti-tumor effects in cells derived from human HCC, but the molecular mechanisms that lead to this, as well as the early transcriptomic response of GDF11 in HCC, remain a mystery. To identify potential targets for therapeutic inter...

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Main Authors: Melissa Sánchez-Rodríguez, Monserrat Gerardo-Ramírez, Arturo Simoni-Nieves, María Concepción Gutiérrez-Ruiz, Roxana U Miranda-Labra, Verónica Souza, Leticia Bucio-Ortiz, Alejandro Escobedo-Calvario, Luis E. Gomez-Quiroz
Format: Article
Language:English
Published: Elsevier 2025-04-01
Series:Annals of Hepatology
Online Access:http://www.sciencedirect.com/science/article/pii/S1665268125000171
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