Hematological effects of coenzyme q10 in streptozotocin-induced diabetic rats
<b>Aim:</b> This study was conducted to evaluate the effects of Coenzyme Q10 on some hematological parameters in streptozotocin-induced diabetic rats.<p> <b>Materials and Methods:</b> In the experiment, 38 healthy, adult male rats were divided into five groups. Group 1...
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Selcuk University Press
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| Series: | Eurasian Journal of Veterinary Sciences |
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| Online Access: | http://eurasianjvetsci.org/pdf.php3?id=1173 |
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| _version_ | 1832543837405315072 |
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| author | Ercan Keskin Deniz Uluışık |
| author_facet | Ercan Keskin Deniz Uluışık |
| author_sort | Ercan Keskin |
| collection | DOAJ |
| description | <b>Aim:</b> This study was conducted to evaluate the effects of Coenzyme
Q10 on some hematological parameters in streptozotocin-induced
diabetic rats.<p>
<b>Materials and Methods:</b> In the experiment, 38 healthy,
adult male rats were divided into five groups. Group 1 was
fed standard rat pellets for four weeks. Group 2 was administered
with 0,3 ml corn oil IP daily for four weeks, group 3 was
injected IP with 10 mg/kg CoQ10 daily for four weeks, group
4 was made diabetic by SC injections of 40 mg/kg streptozotocin
as single daily dose for two days, group 5 was made
diabetic by SC injections of streptozotocin in the same way
and then was injected IP with 10 mg/kg CoQ10 daily for four
weeks. In blood samples received from all animals, red blood
cells (RBC) and white blood cells (WBC) counts, hemoglobin
amount, hematocrit value (PCV), differential leucocyte counts
and mean cell volume (MCV), mean corpuscular hemoglobin
(MCH), mean corpuscular hemoglobin concentration
(MCHC) were determined.<p>
<b>Results:</b> In diabetic rats, RBC, hemoglobin and hematocrit
values were determined to be lower (p<0.05) than the control
group. CoQ10 application to diabetic animals increased
(p<0.05) hematocrit value compared diabetic group. Experimentally
induced diabetes caused significantly (p<0.05)
increments in WBC count and neutrophil percentage, while
lymphocyte percentage was decreased (p<0.05) compared
to control group. CoQ10 treatment to the diabetic group
markedly (p<0.05) decreased the neutrophil percentage and
increased the lymphocyte percentage compared to diabetic
group.<p>
<b>Conclusions:</b> These results showed that CoQ10 treatment to
diabetic rats may have some beneficial properties on hematological
parameters negatively affected from diabetic injury. |
| format | Article |
| id | doaj-art-4094310e60c14b96b1550b9e315b104b |
| institution | Kabale University |
| issn | 1309-6958 2146-1953 |
| language | English |
| publisher | Selcuk University Press |
| record_format | Article |
| series | Eurasian Journal of Veterinary Sciences |
| spelling | doaj-art-4094310e60c14b96b1550b9e315b104b2025-02-03T11:25:39ZengSelcuk University PressEurasian Journal of Veterinary Sciences1309-69582146-19533331671711173Hematological effects of coenzyme q10 in streptozotocin-induced diabetic ratsErcan KeskinDeniz Uluışık<b>Aim:</b> This study was conducted to evaluate the effects of Coenzyme Q10 on some hematological parameters in streptozotocin-induced diabetic rats.<p> <b>Materials and Methods:</b> In the experiment, 38 healthy, adult male rats were divided into five groups. Group 1 was fed standard rat pellets for four weeks. Group 2 was administered with 0,3 ml corn oil IP daily for four weeks, group 3 was injected IP with 10 mg/kg CoQ10 daily for four weeks, group 4 was made diabetic by SC injections of 40 mg/kg streptozotocin as single daily dose for two days, group 5 was made diabetic by SC injections of streptozotocin in the same way and then was injected IP with 10 mg/kg CoQ10 daily for four weeks. In blood samples received from all animals, red blood cells (RBC) and white blood cells (WBC) counts, hemoglobin amount, hematocrit value (PCV), differential leucocyte counts and mean cell volume (MCV), mean corpuscular hemoglobin (MCH), mean corpuscular hemoglobin concentration (MCHC) were determined.<p> <b>Results:</b> In diabetic rats, RBC, hemoglobin and hematocrit values were determined to be lower (p<0.05) than the control group. CoQ10 application to diabetic animals increased (p<0.05) hematocrit value compared diabetic group. Experimentally induced diabetes caused significantly (p<0.05) increments in WBC count and neutrophil percentage, while lymphocyte percentage was decreased (p<0.05) compared to control group. CoQ10 treatment to the diabetic group markedly (p<0.05) decreased the neutrophil percentage and increased the lymphocyte percentage compared to diabetic group.<p> <b>Conclusions:</b> These results showed that CoQ10 treatment to diabetic rats may have some beneficial properties on hematological parameters negatively affected from diabetic injury.http://eurasianjvetsci.org/pdf.php3?id=1173coq10diabeteshematological parametersrats |
| spellingShingle | Ercan Keskin Deniz Uluışık Hematological effects of coenzyme q10 in streptozotocin-induced diabetic rats Eurasian Journal of Veterinary Sciences coq10 diabetes hematological parameters rats |
| title | Hematological effects of coenzyme q10 in streptozotocin-induced diabetic rats |
| title_full | Hematological effects of coenzyme q10 in streptozotocin-induced diabetic rats |
| title_fullStr | Hematological effects of coenzyme q10 in streptozotocin-induced diabetic rats |
| title_full_unstemmed | Hematological effects of coenzyme q10 in streptozotocin-induced diabetic rats |
| title_short | Hematological effects of coenzyme q10 in streptozotocin-induced diabetic rats |
| title_sort | hematological effects of coenzyme q10 in streptozotocin induced diabetic rats |
| topic | coq10 diabetes hematological parameters rats |
| url | http://eurasianjvetsci.org/pdf.php3?id=1173 |
| work_keys_str_mv | AT ercankeskin hematologicaleffectsofcoenzymeq10instreptozotocininduceddiabeticrats AT denizuluısık hematologicaleffectsofcoenzymeq10instreptozotocininduceddiabeticrats |