Hematological effects of coenzyme q10 in streptozotocin-induced diabetic rats
<b>Aim:</b> This study was conducted to evaluate the effects of Coenzyme Q10 on some hematological parameters in streptozotocin-induced diabetic rats.<p> <b>Materials and Methods:</b> In the experiment, 38 healthy, adult male rats were divided into five groups. Group 1...
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| Main Authors: | , |
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| Format: | Article |
| Language: | English |
| Published: |
Selcuk University Press
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| Series: | Eurasian Journal of Veterinary Sciences |
| Subjects: | |
| Online Access: | http://eurasianjvetsci.org/pdf.php3?id=1173 |
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| Summary: | <b>Aim:</b> This study was conducted to evaluate the effects of Coenzyme
Q10 on some hematological parameters in streptozotocin-induced
diabetic rats.<p>
<b>Materials and Methods:</b> In the experiment, 38 healthy,
adult male rats were divided into five groups. Group 1 was
fed standard rat pellets for four weeks. Group 2 was administered
with 0,3 ml corn oil IP daily for four weeks, group 3 was
injected IP with 10 mg/kg CoQ10 daily for four weeks, group
4 was made diabetic by SC injections of 40 mg/kg streptozotocin
as single daily dose for two days, group 5 was made
diabetic by SC injections of streptozotocin in the same way
and then was injected IP with 10 mg/kg CoQ10 daily for four
weeks. In blood samples received from all animals, red blood
cells (RBC) and white blood cells (WBC) counts, hemoglobin
amount, hematocrit value (PCV), differential leucocyte counts
and mean cell volume (MCV), mean corpuscular hemoglobin
(MCH), mean corpuscular hemoglobin concentration
(MCHC) were determined.<p>
<b>Results:</b> In diabetic rats, RBC, hemoglobin and hematocrit
values were determined to be lower (p<0.05) than the control
group. CoQ10 application to diabetic animals increased
(p<0.05) hematocrit value compared diabetic group. Experimentally
induced diabetes caused significantly (p<0.05)
increments in WBC count and neutrophil percentage, while
lymphocyte percentage was decreased (p<0.05) compared
to control group. CoQ10 treatment to the diabetic group
markedly (p<0.05) decreased the neutrophil percentage and
increased the lymphocyte percentage compared to diabetic
group.<p>
<b>Conclusions:</b> These results showed that CoQ10 treatment to
diabetic rats may have some beneficial properties on hematological
parameters negatively affected from diabetic injury. |
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| ISSN: | 1309-6958 2146-1953 |