Opposite Roles of IL-32α Versus IL-32β/γ Isoforms in Promoting Monocyte-Derived Osteoblast/Osteoclast Differentiation and Vascular Calcification in People with HIV

Opposite Roles of IL-32α Versus IL-32β/γ Isoforms in Promoting Monocyte-Derived Osteoblast/Osteoclast Differentiation and Vascular Calcification in People with HIV

People with HIV (PWH) have an increased risk of developing cardiovascular disease (CVD). Our recent data demonstrated that the multi-isoform proinflammatory cytokine IL-32 is upregulated in PWH and is associated with arterial stiffness and subclinical atherosclerosis. However, the mechanisms by whic...

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Main Authors: Hardik Ramani, Aurélie Cleret-Buhot, Mohamed Sylla, Rémi Bunet, Florent Bertrand, Marc-Messier Peet, Carl Chartrand-Lefebvre, Benoit Trottier, Réjean Thomas, Jean-Pierre Routy, Claude Fortin, Valérie Martel-Laferrière, Manel Sadouni, Guy Cloutier, Louise Allard, Jorge R. Kizer, Nicolas Chomont, Petronela Ancuta, David B. Hanna, Robert C. Kaplan, Mohammad-Ali Jenabian, Alan L. Landay, Madeleine Durand, Mohamed El-Far, Cécile L. Tremblay
Format: Article
Language:English
Published: MDPI AG 2025-03-01
Series:Cells
Subjects:
HIV
inflammation
IL-32
cardiovascular diseases
arterial calcification
atherosclerosis
Online Access:https://www.mdpi.com/2073-4409/14/7/481
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