Microglia regulate cortical remyelination via TNFR1-dependent phenotypic polarization

Microglia regulate cortical remyelination via TNFR1-dependent phenotypic polarization

Summary: Microglia are strongly implicated in demyelinating neurodegenerative diseases with increasing evidence for roles in protection and healing, but the mechanisms that control CNS remyelination are poorly understood. Here, we show that microglia-specific deletion of tumor necrosis factor recept...

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Main Authors: Athena Boutou, Ilias Roufagalas, Katerina Politopoulou, Spyros Tastsoglou, Maya Abouzeid, Giorgos Skoufos, Laia Verdu de Juan, Jeong Hun Ko, Vasiliki Kyrargyri, Artemis G. Hatzigeorgiou, Christopher J. Barnum, Raymond J. Tesi, Jan Bauer, Hans Lassmann, Michael R. Johnson, Lesley Probert
Format: Article
Language:English
Published: Elsevier 2024-11-01
Series:Cell Reports
Subjects:
CP: Neuroscience
CP: Immunology
Online Access:http://www.sciencedirect.com/science/article/pii/S2211124724012452
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