Host FSTL1 defines the impact of stem cell therapy on liver fibrosis by potentiating the early recruitment of inflammatory macrophages

Host FSTL1 defines the impact of stem cell therapy on liver fibrosis by potentiating the early recruitment of inflammatory macrophages

Abstract Adult stem cell therapy holds great promise for treating decompensated liver cirrhosis on the basis of animal studies, despite uncertainty about its clinical therapeutic efficacy and unclear underlying mechanisms. Here, we investigated the role of follistatin-like 1 (FSTL1), a profibrotic a...

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Main Authors: Xiaohong Zheng, Siyuan Tian, Ting Li, Si Zhang, Xia Zhou, Yansheng Liu, Rui Su, Miao Zhang, Bo Li, Chao Qi, Guanya Guo, Shuoyi Ma, Keshuai Sun, Fangfang Yang, Yinan Hu, Chunmei Yang, Lina Cui, Yulong Shang, Changcun Guo, Boquan Jin, Lei Guan, Jingbo Wang, Wen Ning, Ying Han
Format: Article
Language:English
Published: Nature Publishing Group 2025-03-01
Series:Signal Transduction and Targeted Therapy
Online Access:https://doi.org/10.1038/s41392-025-02162-6
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https://doi.org/10.1038/s41392-025-02162-6

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