Case Report: Failure of eculizumab to block complement to prevent relapse of anti-phospholipid syndrome in kidney transplant recipient

Case Report: Failure of eculizumab to block complement to prevent relapse of anti-phospholipid syndrome in kidney transplant recipient

Catastrophic antiphospholipid syndrome (CAPS) leads to organ dysfunction due to thrombotic microangiopathy (TMA). Complement may play a role in CAPS, and its blockade could prevent antiphospholipid syndrome (APS) complications after kidney transplantation (KT). Here, we report a case of APS recurren...

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Bibliographic Details
Main Authors: Thibault Laban, Fredéric Pigneur, Constance Guillaud, Marie Agnès Dragon Durey, Houcine Hamidi, Caroline Pilon, Marc Michel, Nizar Joher, Philippe Grimbert, Hamza Sakhi, Antoine Morel, Marie Matignon
Format: Article
Language:English
Published: Frontiers Media S.A. 2025-06-01
Series:Frontiers in Nephrology
Subjects:
kidney transplantation
antiphospholipid syndrome
eculizumab
thrombotic micro angiopathy
cortical necrosis
Online Access:https://www.frontiersin.org/articles/10.3389/fneph.2025.1572641/full
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https://www.frontiersin.org/articles/10.3389/fneph.2025.1572641/full

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