2-O-β-D-Glucopyranosyl-L-ascorbic acid, an ascorbic acid derivative isolated from the fruits of Lycium barbarum L., ameliorates high fructose-induced neuroinflammation in mice: involvement of gut microbiota and leaky gut
Western diet (rich in highly refined sugar and fat) can induce a range of metabolic dysfunctions in animals and humans, including neuroinflammation and cognitive function decline. Neuroinflammation and cognitive impairment, two critical pathological characteristics of Alzheimer’s disease, have been...
Saved in:
| Main Authors: | , , , , , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Tsinghua University Press
2024-01-01
|
| Series: | Food Science and Human Wellness |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S2213453023001155 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1832553389667385344 |
|---|---|
| author | Wei Dong Yujia Peng Guijie Chen Zhiyong Xie Weiqi Xu Wangting Zhou Jia Mi Lu Lu Yi Sun Xiaoxiong Zeng Youlong Cao Yamei Yan |
| author_facet | Wei Dong Yujia Peng Guijie Chen Zhiyong Xie Weiqi Xu Wangting Zhou Jia Mi Lu Lu Yi Sun Xiaoxiong Zeng Youlong Cao Yamei Yan |
| author_sort | Wei Dong |
| collection | DOAJ |
| description | Western diet (rich in highly refined sugar and fat) can induce a range of metabolic dysfunctions in animals and humans, including neuroinflammation and cognitive function decline. Neuroinflammation and cognitive impairment, two critical pathological characteristics of Alzheimer’s disease, have been closely associated with microbial alteration via the gut-brain axis. Thus, the present study aimed to investigate the influence of 2-O-β-D-glucopyranosyl-L-ascorbic acid (AA-2βG) isolated from the fruits of Lycium barbarum on preventing the high-fructose diet (HFrD) induced neuroinflammation in mice. It was found that AA-2βG prevented HFrD-induced cognitive deficits. AA-2βG also predominantly enhanced the gut barrier integrity, decreased lipopolysaccharide entry into the circulation, which subsequently countered the activation of glial cells and neuroinflammatory response. These beneficial effects were transmissible by horizontal fecal microbiome transplantation, transferring from AA-2βG fed mice to HFrD fed mice. Additionally, AA-2βG exerted neuroprotective effects involving the enrichment of Lactobacillus and Akkermansia, potentially beneficial intestinal bacteria. The present study provided the evidence that AA-2βG could improve indices of cognition and neuroinflammmation via modulating gut dybiosis and preventing leaky gut. As a potential functional food ingredient, AA-2βG may be applied to attenuate neuroinflammation associated with Western-style diets. |
| format | Article |
| id | doaj-art-3fd55da79fdd4addaf1e046fa356174f |
| institution | Kabale University |
| issn | 2213-4530 |
| language | English |
| publishDate | 2024-01-01 |
| publisher | Tsinghua University Press |
| record_format | Article |
| series | Food Science and Human Wellness |
| spelling | doaj-art-3fd55da79fdd4addaf1e046fa356174f2025-02-03T05:54:06ZengTsinghua University PressFood Science and Human Wellness2213-45302024-01-011312412532-O-β-D-Glucopyranosyl-L-ascorbic acid, an ascorbic acid derivative isolated from the fruits of Lycium barbarum L., ameliorates high fructose-induced neuroinflammation in mice: involvement of gut microbiota and leaky gutWei Dong0Yujia Peng1Guijie Chen2Zhiyong Xie3Weiqi Xu4Wangting Zhou5Jia Mi6Lu Lu7Yi Sun8Xiaoxiong Zeng9Youlong Cao10Yamei Yan11College of Food Science and Technology, Nanjing Agricultural University, Nanjing 210095, ChinaCollege of Food Science and Technology, Nanjing Agricultural University, Nanjing 210095, ChinaCollege of Food Science and Technology, Nanjing Agricultural University, Nanjing 210095, ChinaCollege of Food Science and Technology, Nanjing Agricultural University, Nanjing 210095, ChinaCollege of Food Science and Technology, Nanjing Agricultural University, Nanjing 210095, ChinaCollege of Food Science and Technology, Nanjing Agricultural University, Nanjing 210095, ChinaInstitute of Wolfberry Engineering Technology, National Wolfberry Engineering Research Center, Ningxia Academy of Agriculture and Forestry Sciences, Yinchuan 750002, ChinaInstitute of Wolfberry Engineering Technology, National Wolfberry Engineering Research Center, Ningxia Academy of Agriculture and Forestry Sciences, Yinchuan 750002, ChinaCollege of Food Science and Technology, Nanjing Agricultural University, Nanjing 210095, ChinaCollege of Food Science and Technology, Nanjing Agricultural University, Nanjing 210095, China; Corresponding authors.Institute of Wolfberry Engineering Technology, National Wolfberry Engineering Research Center, Ningxia Academy of Agriculture and Forestry Sciences, Yinchuan 750002, China; Corresponding authors.Institute of Wolfberry Engineering Technology, National Wolfberry Engineering Research Center, Ningxia Academy of Agriculture and Forestry Sciences, Yinchuan 750002, China; Corresponding authors.Western diet (rich in highly refined sugar and fat) can induce a range of metabolic dysfunctions in animals and humans, including neuroinflammation and cognitive function decline. Neuroinflammation and cognitive impairment, two critical pathological characteristics of Alzheimer’s disease, have been closely associated with microbial alteration via the gut-brain axis. Thus, the present study aimed to investigate the influence of 2-O-β-D-glucopyranosyl-L-ascorbic acid (AA-2βG) isolated from the fruits of Lycium barbarum on preventing the high-fructose diet (HFrD) induced neuroinflammation in mice. It was found that AA-2βG prevented HFrD-induced cognitive deficits. AA-2βG also predominantly enhanced the gut barrier integrity, decreased lipopolysaccharide entry into the circulation, which subsequently countered the activation of glial cells and neuroinflammatory response. These beneficial effects were transmissible by horizontal fecal microbiome transplantation, transferring from AA-2βG fed mice to HFrD fed mice. Additionally, AA-2βG exerted neuroprotective effects involving the enrichment of Lactobacillus and Akkermansia, potentially beneficial intestinal bacteria. The present study provided the evidence that AA-2βG could improve indices of cognition and neuroinflammmation via modulating gut dybiosis and preventing leaky gut. As a potential functional food ingredient, AA-2βG may be applied to attenuate neuroinflammation associated with Western-style diets.http://www.sciencedirect.com/science/article/pii/S2213453023001155NeuroinflammationGut microbiotaLeaky gutLipopolysaccharideFecal microbiome transplantation2-O-β-D-Glucopyranosyl-L-ascorbic acid |
| spellingShingle | Wei Dong Yujia Peng Guijie Chen Zhiyong Xie Weiqi Xu Wangting Zhou Jia Mi Lu Lu Yi Sun Xiaoxiong Zeng Youlong Cao Yamei Yan 2-O-β-D-Glucopyranosyl-L-ascorbic acid, an ascorbic acid derivative isolated from the fruits of Lycium barbarum L., ameliorates high fructose-induced neuroinflammation in mice: involvement of gut microbiota and leaky gut Food Science and Human Wellness Neuroinflammation Gut microbiota Leaky gut Lipopolysaccharide Fecal microbiome transplantation 2-O-β-D-Glucopyranosyl-L-ascorbic acid |
| title | 2-O-β-D-Glucopyranosyl-L-ascorbic acid, an ascorbic acid derivative isolated from the fruits of Lycium barbarum L., ameliorates high fructose-induced neuroinflammation in mice: involvement of gut microbiota and leaky gut |
| title_full | 2-O-β-D-Glucopyranosyl-L-ascorbic acid, an ascorbic acid derivative isolated from the fruits of Lycium barbarum L., ameliorates high fructose-induced neuroinflammation in mice: involvement of gut microbiota and leaky gut |
| title_fullStr | 2-O-β-D-Glucopyranosyl-L-ascorbic acid, an ascorbic acid derivative isolated from the fruits of Lycium barbarum L., ameliorates high fructose-induced neuroinflammation in mice: involvement of gut microbiota and leaky gut |
| title_full_unstemmed | 2-O-β-D-Glucopyranosyl-L-ascorbic acid, an ascorbic acid derivative isolated from the fruits of Lycium barbarum L., ameliorates high fructose-induced neuroinflammation in mice: involvement of gut microbiota and leaky gut |
| title_short | 2-O-β-D-Glucopyranosyl-L-ascorbic acid, an ascorbic acid derivative isolated from the fruits of Lycium barbarum L., ameliorates high fructose-induced neuroinflammation in mice: involvement of gut microbiota and leaky gut |
| title_sort | 2 o β d glucopyranosyl l ascorbic acid an ascorbic acid derivative isolated from the fruits of lycium barbarum l ameliorates high fructose induced neuroinflammation in mice involvement of gut microbiota and leaky gut |
| topic | Neuroinflammation Gut microbiota Leaky gut Lipopolysaccharide Fecal microbiome transplantation 2-O-β-D-Glucopyranosyl-L-ascorbic acid |
| url | http://www.sciencedirect.com/science/article/pii/S2213453023001155 |
| work_keys_str_mv | AT weidong 2obdglucopyranosyllascorbicacidanascorbicacidderivativeisolatedfromthefruitsoflyciumbarbarumlameliorateshighfructoseinducedneuroinflammationinmiceinvolvementofgutmicrobiotaandleakygut AT yujiapeng 2obdglucopyranosyllascorbicacidanascorbicacidderivativeisolatedfromthefruitsoflyciumbarbarumlameliorateshighfructoseinducedneuroinflammationinmiceinvolvementofgutmicrobiotaandleakygut AT guijiechen 2obdglucopyranosyllascorbicacidanascorbicacidderivativeisolatedfromthefruitsoflyciumbarbarumlameliorateshighfructoseinducedneuroinflammationinmiceinvolvementofgutmicrobiotaandleakygut AT zhiyongxie 2obdglucopyranosyllascorbicacidanascorbicacidderivativeisolatedfromthefruitsoflyciumbarbarumlameliorateshighfructoseinducedneuroinflammationinmiceinvolvementofgutmicrobiotaandleakygut AT weiqixu 2obdglucopyranosyllascorbicacidanascorbicacidderivativeisolatedfromthefruitsoflyciumbarbarumlameliorateshighfructoseinducedneuroinflammationinmiceinvolvementofgutmicrobiotaandleakygut AT wangtingzhou 2obdglucopyranosyllascorbicacidanascorbicacidderivativeisolatedfromthefruitsoflyciumbarbarumlameliorateshighfructoseinducedneuroinflammationinmiceinvolvementofgutmicrobiotaandleakygut AT jiami 2obdglucopyranosyllascorbicacidanascorbicacidderivativeisolatedfromthefruitsoflyciumbarbarumlameliorateshighfructoseinducedneuroinflammationinmiceinvolvementofgutmicrobiotaandleakygut AT lulu 2obdglucopyranosyllascorbicacidanascorbicacidderivativeisolatedfromthefruitsoflyciumbarbarumlameliorateshighfructoseinducedneuroinflammationinmiceinvolvementofgutmicrobiotaandleakygut AT yisun 2obdglucopyranosyllascorbicacidanascorbicacidderivativeisolatedfromthefruitsoflyciumbarbarumlameliorateshighfructoseinducedneuroinflammationinmiceinvolvementofgutmicrobiotaandleakygut AT xiaoxiongzeng 2obdglucopyranosyllascorbicacidanascorbicacidderivativeisolatedfromthefruitsoflyciumbarbarumlameliorateshighfructoseinducedneuroinflammationinmiceinvolvementofgutmicrobiotaandleakygut AT youlongcao 2obdglucopyranosyllascorbicacidanascorbicacidderivativeisolatedfromthefruitsoflyciumbarbarumlameliorateshighfructoseinducedneuroinflammationinmiceinvolvementofgutmicrobiotaandleakygut AT yameiyan 2obdglucopyranosyllascorbicacidanascorbicacidderivativeisolatedfromthefruitsoflyciumbarbarumlameliorateshighfructoseinducedneuroinflammationinmiceinvolvementofgutmicrobiotaandleakygut |