GLP-1 Relaxes Rat Coronary Arteries by Enhancing ATP-Sensitive Potassium Channel Currents
GLP-1 is a new type of antidiabetic agent that possesses many beneficial effects. Although its cardiovascular actions have been widely examined, little is known about GLP-1’s effects on the rat coronary artery (RCA) or about the mechanisms underpinning these effects. Here, we report that GLP-1 inhib...
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| Format: | Article |
| Language: | English |
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Wiley
2019-01-01
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| Series: | Cardiology Research and Practice |
| Online Access: | http://dx.doi.org/10.1155/2019/1968785 |
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| author | Qian-Feng Xiong Shao-Hua Fan Xue-Wen Li Yu Niu Jing Wang Xin Zhang Yi-Fan Chen Ya-Wei Shi Li-Hui Zhang |
| author_facet | Qian-Feng Xiong Shao-Hua Fan Xue-Wen Li Yu Niu Jing Wang Xin Zhang Yi-Fan Chen Ya-Wei Shi Li-Hui Zhang |
| author_sort | Qian-Feng Xiong |
| collection | DOAJ |
| description | GLP-1 is a new type of antidiabetic agent that possesses many beneficial effects. Although its cardiovascular actions have been widely examined, little is known about GLP-1’s effects on the rat coronary artery (RCA) or about the mechanisms underpinning these effects. Here, we report that GLP-1 inhibits depolarization- or thromboxane receptor agonist (U46619)-induced RCA contraction in a dosage-dependent manner. Vasorelaxation was attenuated by denuding the endothelium, L-NAME (nitric oxide synthase inhibitor), and glyburide (KATP channel blocker) but was not affected by indomethacin (cyclooxygenase inhibitor), iberiotoxin [Ca2+-activated K+ channel (KCa) blocker], or 4-aminopyridine (KV channel blocker). Furthermore, GLP-1 increased outward K+ currents by enhancing the KATP channel in rat coronary arterial smooth muscle cells (RCASMCs). These results show that GLP-1 is an endothelial-dependent vasospasmolytic agent in the RCA and imply that the relaxant effect is regulated by enhancing KATP rather than KV or KCa currents in RCASMCs. |
| format | Article |
| id | doaj-art-3faa9fb781da4653a8fcea9581e427e0 |
| institution | Kabale University |
| issn | 2090-8016 2090-0597 |
| language | English |
| publishDate | 2019-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Cardiology Research and Practice |
| spelling | doaj-art-3faa9fb781da4653a8fcea9581e427e02025-02-03T01:02:16ZengWileyCardiology Research and Practice2090-80162090-05972019-01-01201910.1155/2019/19687851968785GLP-1 Relaxes Rat Coronary Arteries by Enhancing ATP-Sensitive Potassium Channel CurrentsQian-Feng Xiong0Shao-Hua Fan1Xue-Wen Li2Yu Niu3Jing Wang4Xin Zhang5Yi-Fan Chen6Ya-Wei Shi7Li-Hui Zhang8Department of Cardiology, Fengcheng People’s Hospital, Fengcheng 331100, Jiangxi, ChinaKey Laboratory of Chemical Biology and Molecular Engineering of Ministry of Education, Institute of Biotechnology, Shanxi University, Taiyuan 030006, Shanxi, ChinaDepartment of Cardiology, Shanxi Dayi Hospital Affiliated to Shanxi Medical University, Taiyuan 030024, Shanxi, ChinaDepartment of Cardiology, Shanxi Dayi Hospital Affiliated to Shanxi Medical University, Taiyuan 030024, Shanxi, ChinaDepartment of Cardiology, Shanxi Dayi Hospital Affiliated to Shanxi Medical University, Taiyuan 030024, Shanxi, ChinaKey Laboratory of Chemical Biology and Molecular Engineering of Ministry of Education, Institute of Biotechnology, Shanxi University, Taiyuan 030006, Shanxi, ChinaDepartment of Cardiology, Shanxi Dayi Hospital Affiliated to Shanxi Medical University, Taiyuan 030024, Shanxi, ChinaKey Laboratory of Chemical Biology and Molecular Engineering of Ministry of Education, Institute of Biotechnology, Shanxi University, Taiyuan 030006, Shanxi, ChinaDepartment of Geriatrics, Shanxi Dayi Hospital Affiliated to Shanxi Medical University, Taiyuan 030024, Shanxi, ChinaGLP-1 is a new type of antidiabetic agent that possesses many beneficial effects. Although its cardiovascular actions have been widely examined, little is known about GLP-1’s effects on the rat coronary artery (RCA) or about the mechanisms underpinning these effects. Here, we report that GLP-1 inhibits depolarization- or thromboxane receptor agonist (U46619)-induced RCA contraction in a dosage-dependent manner. Vasorelaxation was attenuated by denuding the endothelium, L-NAME (nitric oxide synthase inhibitor), and glyburide (KATP channel blocker) but was not affected by indomethacin (cyclooxygenase inhibitor), iberiotoxin [Ca2+-activated K+ channel (KCa) blocker], or 4-aminopyridine (KV channel blocker). Furthermore, GLP-1 increased outward K+ currents by enhancing the KATP channel in rat coronary arterial smooth muscle cells (RCASMCs). These results show that GLP-1 is an endothelial-dependent vasospasmolytic agent in the RCA and imply that the relaxant effect is regulated by enhancing KATP rather than KV or KCa currents in RCASMCs.http://dx.doi.org/10.1155/2019/1968785 |
| spellingShingle | Qian-Feng Xiong Shao-Hua Fan Xue-Wen Li Yu Niu Jing Wang Xin Zhang Yi-Fan Chen Ya-Wei Shi Li-Hui Zhang GLP-1 Relaxes Rat Coronary Arteries by Enhancing ATP-Sensitive Potassium Channel Currents Cardiology Research and Practice |
| title | GLP-1 Relaxes Rat Coronary Arteries by Enhancing ATP-Sensitive Potassium Channel Currents |
| title_full | GLP-1 Relaxes Rat Coronary Arteries by Enhancing ATP-Sensitive Potassium Channel Currents |
| title_fullStr | GLP-1 Relaxes Rat Coronary Arteries by Enhancing ATP-Sensitive Potassium Channel Currents |
| title_full_unstemmed | GLP-1 Relaxes Rat Coronary Arteries by Enhancing ATP-Sensitive Potassium Channel Currents |
| title_short | GLP-1 Relaxes Rat Coronary Arteries by Enhancing ATP-Sensitive Potassium Channel Currents |
| title_sort | glp 1 relaxes rat coronary arteries by enhancing atp sensitive potassium channel currents |
| url | http://dx.doi.org/10.1155/2019/1968785 |
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