Palmitoylation as a Functional Regulator of Neurotransmitter Receptors
The majority of neuronal proteins involved in cellular signaling undergo different posttranslational modifications significantly affecting their functions. One of these modifications is a covalent attachment of a 16-C palmitic acid to one or more cysteine residues (S-palmitoylation) within the targe...
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| Format: | Article |
| Language: | English |
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Wiley
2018-01-01
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| Series: | Neural Plasticity |
| Online Access: | http://dx.doi.org/10.1155/2018/5701348 |
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| author | Vladimir S. Naumenko Evgeni Ponimaskin |
| author_facet | Vladimir S. Naumenko Evgeni Ponimaskin |
| author_sort | Vladimir S. Naumenko |
| collection | DOAJ |
| description | The majority of neuronal proteins involved in cellular signaling undergo different posttranslational modifications significantly affecting their functions. One of these modifications is a covalent attachment of a 16-C palmitic acid to one or more cysteine residues (S-palmitoylation) within the target protein. Palmitoylation is a reversible modification, and repeated cycles of palmitoylation/depalmitoylation might be critically involved in the regulation of multiple signaling processes. Palmitoylation also represents a common posttranslational modification of the neurotransmitter receptors, including G protein-coupled receptors (GPCRs) and ligand-gated ion channels (LICs). From the functional point of view, palmitoylation affects a wide span of neurotransmitter receptors activities including their trafficking, sorting, stability, residence lifetime at the cell surface, endocytosis, recycling, and synaptic clustering. This review summarizes the current knowledge on the palmitoylation of neurotransmitter receptors and its role in the regulation of receptors functions as well as in the control of different kinds of physiological and pathological behavior. |
| format | Article |
| id | doaj-art-3f7aeda4dc5545b69df37de5e368c12e |
| institution | Kabale University |
| issn | 2090-5904 1687-5443 |
| language | English |
| publishDate | 2018-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Neural Plasticity |
| spelling | doaj-art-3f7aeda4dc5545b69df37de5e368c12e2025-02-03T05:44:32ZengWileyNeural Plasticity2090-59041687-54432018-01-01201810.1155/2018/57013485701348Palmitoylation as a Functional Regulator of Neurotransmitter ReceptorsVladimir S. Naumenko0Evgeni Ponimaskin1Federal Research Center Institute of Cytology and Genetics, Siberian Division of the Russian Academy of Science, Novosibirsk, RussiaCellular Neurophysiology, Hannover Medical School, Hannover, GermanyThe majority of neuronal proteins involved in cellular signaling undergo different posttranslational modifications significantly affecting their functions. One of these modifications is a covalent attachment of a 16-C palmitic acid to one or more cysteine residues (S-palmitoylation) within the target protein. Palmitoylation is a reversible modification, and repeated cycles of palmitoylation/depalmitoylation might be critically involved in the regulation of multiple signaling processes. Palmitoylation also represents a common posttranslational modification of the neurotransmitter receptors, including G protein-coupled receptors (GPCRs) and ligand-gated ion channels (LICs). From the functional point of view, palmitoylation affects a wide span of neurotransmitter receptors activities including their trafficking, sorting, stability, residence lifetime at the cell surface, endocytosis, recycling, and synaptic clustering. This review summarizes the current knowledge on the palmitoylation of neurotransmitter receptors and its role in the regulation of receptors functions as well as in the control of different kinds of physiological and pathological behavior.http://dx.doi.org/10.1155/2018/5701348 |
| spellingShingle | Vladimir S. Naumenko Evgeni Ponimaskin Palmitoylation as a Functional Regulator of Neurotransmitter Receptors Neural Plasticity |
| title | Palmitoylation as a Functional Regulator of Neurotransmitter Receptors |
| title_full | Palmitoylation as a Functional Regulator of Neurotransmitter Receptors |
| title_fullStr | Palmitoylation as a Functional Regulator of Neurotransmitter Receptors |
| title_full_unstemmed | Palmitoylation as a Functional Regulator of Neurotransmitter Receptors |
| title_short | Palmitoylation as a Functional Regulator of Neurotransmitter Receptors |
| title_sort | palmitoylation as a functional regulator of neurotransmitter receptors |
| url | http://dx.doi.org/10.1155/2018/5701348 |
| work_keys_str_mv | AT vladimirsnaumenko palmitoylationasafunctionalregulatorofneurotransmitterreceptors AT evgeniponimaskin palmitoylationasafunctionalregulatorofneurotransmitterreceptors |