Chondrocyte lysates activate NLRP3 inflammasome-induced pyroptosis in synovial fibroblasts to exacerbate knee synovitis by downregulating caveolin-1

Chondrocyte lysates activate NLRP3 inflammasome-induced pyroptosis in synovial fibroblasts to exacerbate knee synovitis by downregulating caveolin-1

Abstract Background Synovitis, among the most common signs of early-stage osteoarthritis (OA), is mainly mediated by fibroblast-like synoviocytes (FLSs). Cartilage destruction creates chondrocyte lysates (CLs) that activate synovial inflammation. A comprehensive understanding of chondrocyte–FLS comm...

Full description

Saved in:
Bibliographic Details
Main Authors: Xue Du, Ruonan Liu, Zongrui Jiang, Chengyun Zhang, Zhijian Yang, Shu Hu, Zhiqi Zhang
Format: Article
Language:English
Published: BMC 2025-05-01
Series:Arthritis Research & Therapy
Subjects:
Caveolin-1
Chondrocyte lysate
Fibroblast-like synoviocyte
LIM-containing lipoma preferred partner
NLRP3
Online Access:https://doi.org/10.1186/s13075-025-03573-0
Tags: Add Tag
No Tags, Be the first to tag this record!

Internet

https://doi.org/10.1186/s13075-025-03573-0

Similar Items