Preliminary clinical activity of TP-0903 in relapsed or refractory acute myeloid leukemia with FLT3-ITD mutations

Preliminary clinical activity of TP-0903 in relapsed or refractory acute myeloid leukemia with FLT3-ITD mutations

Acute myeloid leukemia (AML) patients with FMS-like tyrosine kinase 3 internal tandem duplication (FLT3-ITD) experience shorter disease-free survival and high relapse rates even with FLT3 inhibitor therapy. One of the main mechanisms for loss of response is the acquisition of molecular mutations tha...

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Main Authors: Bhavana Bhatnagar, Daelynn R. Buelow, Kaitlyn M. Dvorak-Kornaus, Shelley J. Orwick, Jae Yoon Jeon, Zahra Talebi, Amy S. Ruppert, James S. Blachly, Uma Borate, Sharyn D. Baker
Format: Article
Language:English
Published: Frontiers Media S.A. 2025-04-01
Series:Frontiers in Hematology
Subjects:
acute myeloid leukemia
AML
relapsed/refractory
clinical trial
TP-0903
Online Access:https://www.frontiersin.org/articles/10.3389/frhem.2025.1554764/full
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https://www.frontiersin.org/articles/10.3389/frhem.2025.1554764/full

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