Spatial, transcriptomic, and epigenomic analyses link dorsal horn neurons to chronic pain genetic predisposition

Spatial, transcriptomic, and epigenomic analyses link dorsal horn neurons to chronic pain genetic predisposition

Summary: Key mechanisms underlying chronic pain occur within the dorsal horn. Genome-wide association studies (GWASs) have identified genetic variants predisposed to chronic pain. However, most of these variants lie within regulatory non-coding regions that have not been linked to spinal cord biolog...

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Main Authors: Cynthia M. Arokiaraj, Michael J. Leone, Michael Kleyman, Alexander Chamessian, Myung-Chul Noh, BaDoi N. Phan, Bettega C. Lopes, Kelly A. Corrigan, Vijay Kiran Cherupally, Deepika Yeramosu, Michael E. Franusich, Riya Podder, Sumitra Lele, Stephanie Shiers, Byungsoo Kang, Meaghan M. Kennedy, Viola Chen, Ziheng Chen, Hansruedi Mathys, Richard P. Dum, David A. Lewis, Yawar Qadri, Theodore J. Price, Andreas R. Pfenning, Rebecca P. Seal
Format: Article
Language:English
Published: Elsevier 2024-11-01
Series:Cell Reports
Subjects:
CP: Neuroscience
Online Access:http://www.sciencedirect.com/science/article/pii/S2211124724012270
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