A Case of Cerebral Vasculitis Associated with Ulcerative Colitis
Ulcerative colitis (UC) is a chronic, debilitating condition characterized by inflammation of the colonic mucosa. It is regarded as a systemic inflammatory disorder that can affect a number of organ systems. Central nervous system disease associated with UC is a rare sequela of inflammatory bowel di...
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| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
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Wiley
2015-01-01
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| Series: | Case Reports in Rheumatology |
| Online Access: | http://dx.doi.org/10.1155/2015/598273 |
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| _version_ | 1832550267984281600 |
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| author | Naveen Raj Matthew Arkebauer Barry Waters Brucha Dickinson |
| author_facet | Naveen Raj Matthew Arkebauer Barry Waters Brucha Dickinson |
| author_sort | Naveen Raj |
| collection | DOAJ |
| description | Ulcerative colitis (UC) is a chronic, debilitating condition characterized by inflammation of the colonic mucosa. It is regarded as a systemic inflammatory disorder that can affect a number of organ systems. Central nervous system disease associated with UC is a rare sequela of inflammatory bowel disease, occurring in less than 5% of cases. These manifestations include arterial and venous thrombosis, leukoencephalitis, seizures, and vasculitis. We present a case of a 61-year-old female with a two-year history of well-controlled ulcerative colitis, who developed altered mental status and weakness. On brain imaging, she was found to have cerebral lesions which were biopsied. Histopathology subsequently revealed coagulative necrosis and inflammation characteristic of vasculitis. Rheumatology serologies were negative, and the patient was started on steroids that dramatically improved her neurological function, with no residual deficits, and led to resolution of the brain lesions. |
| format | Article |
| id | doaj-art-3f35c7174cdc49f7afcc6301d5f993e6 |
| institution | Kabale University |
| issn | 2090-6889 2090-6897 |
| language | English |
| publishDate | 2015-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Case Reports in Rheumatology |
| spelling | doaj-art-3f35c7174cdc49f7afcc6301d5f993e62025-02-03T06:07:17ZengWileyCase Reports in Rheumatology2090-68892090-68972015-01-01201510.1155/2015/598273598273A Case of Cerebral Vasculitis Associated with Ulcerative ColitisNaveen Raj0Matthew Arkebauer1Barry Waters2Brucha Dickinson3Department of Rheumatology, Nova Southeastern University, Larkin Community Hospital, Miami, FL, USADepartment of Rheumatology, Nova Southeastern University, Larkin Community Hospital, Miami, FL, USANova Southeastern University, Larkin Community Hospital, USADepartment of Pathology, Florida Medical Center, Fort Lauderdale, FL, USAUlcerative colitis (UC) is a chronic, debilitating condition characterized by inflammation of the colonic mucosa. It is regarded as a systemic inflammatory disorder that can affect a number of organ systems. Central nervous system disease associated with UC is a rare sequela of inflammatory bowel disease, occurring in less than 5% of cases. These manifestations include arterial and venous thrombosis, leukoencephalitis, seizures, and vasculitis. We present a case of a 61-year-old female with a two-year history of well-controlled ulcerative colitis, who developed altered mental status and weakness. On brain imaging, she was found to have cerebral lesions which were biopsied. Histopathology subsequently revealed coagulative necrosis and inflammation characteristic of vasculitis. Rheumatology serologies were negative, and the patient was started on steroids that dramatically improved her neurological function, with no residual deficits, and led to resolution of the brain lesions.http://dx.doi.org/10.1155/2015/598273 |
| spellingShingle | Naveen Raj Matthew Arkebauer Barry Waters Brucha Dickinson A Case of Cerebral Vasculitis Associated with Ulcerative Colitis Case Reports in Rheumatology |
| title | A Case of Cerebral Vasculitis Associated with Ulcerative Colitis |
| title_full | A Case of Cerebral Vasculitis Associated with Ulcerative Colitis |
| title_fullStr | A Case of Cerebral Vasculitis Associated with Ulcerative Colitis |
| title_full_unstemmed | A Case of Cerebral Vasculitis Associated with Ulcerative Colitis |
| title_short | A Case of Cerebral Vasculitis Associated with Ulcerative Colitis |
| title_sort | case of cerebral vasculitis associated with ulcerative colitis |
| url | http://dx.doi.org/10.1155/2015/598273 |
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