The Levels of Tumor Necrosis Factor-Alpha and Interleukin-6 in Patients with Isolated Coronary Artery Ectasia
Background/Aim. Coronary artery ectasia (CAE) is considered as a variant of atherosclerosis. Tumor necrosis factor-alpha (TNF-𝛼) and interleukin-6 (IL-6) are among the sensitive markers of systemic inflammation. The aim of this study was to evaluate the plasma levels of the cytokines; TNF-𝛼 and IL-...
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| Format: | Article |
| Language: | English |
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Wiley
2009-01-01
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| Series: | Mediators of Inflammation |
| Online Access: | http://dx.doi.org/10.1155/2009/106145 |
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| author | Mustafa Aydin Ishak Ozel Tekin Sait Mesut Dogan Nesligul Yildirim Mehmet Arasli Muhammet Rasit Sayin Ziyaettin Aktop |
| author_facet | Mustafa Aydin Ishak Ozel Tekin Sait Mesut Dogan Nesligul Yildirim Mehmet Arasli Muhammet Rasit Sayin Ziyaettin Aktop |
| author_sort | Mustafa Aydin |
| collection | DOAJ |
| description | Background/Aim. Coronary artery ectasia (CAE) is considered as a variant of atherosclerosis. Tumor necrosis
factor-alpha (TNF-𝛼) and interleukin-6 (IL-6) are among the sensitive
markers of systemic inflammation. The aim of this study was to
evaluate the plasma levels of the cytokines; TNF-𝛼 and IL-6 in CAE patients. Methods. Plasma
concentrations of TNF-𝛼 and IL-6 were measured in 36 patients with CAE (28
males, mean age: 58.2±12 years), and results were compared with age and
sex-matched controls (n=32) without coronary artery ectasia. TNF-𝛼 and IL-6 concentrations in blood were assesed by
enzyme-linked immunosorbent assay (ELISA). Results.
Baseline characteristics of the two groups were similar.
TNF-𝛼 and IL-6 levels were significantly higher in CAE group
than controls (15.6±11.2 pg/mL versus 7.8±3.7 pg/mL, 𝑃<.001, and 17.2±12.6 versus 7.6±2.1 𝑃<.0001, resp.). Conclusion. CAE patients showed
increases in TNF-𝛼 and IL-6 levels compared to the controls. This study
provides evidence for alterations in the proinflamatory cytokines
which suggest the involvement of the immune system in the
pathophysiology of CAE. Further placebo-controlled studies are
needed to evaluate the clinical significance of this increase in
TNF-𝛼 and IL-6 levels. |
| format | Article |
| id | doaj-art-3f1056c55cd14ee59098b5765ab2580f |
| institution | Kabale University |
| issn | 0962-9351 1466-1861 |
| language | English |
| publishDate | 2009-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Mediators of Inflammation |
| spelling | doaj-art-3f1056c55cd14ee59098b5765ab2580f2025-02-03T00:59:20ZengWileyMediators of Inflammation0962-93511466-18612009-01-01200910.1155/2009/106145106145The Levels of Tumor Necrosis Factor-Alpha and Interleukin-6 in Patients with Isolated Coronary Artery EctasiaMustafa Aydin0Ishak Ozel Tekin1Sait Mesut Dogan2Nesligul Yildirim3Mehmet Arasli4Muhammet Rasit Sayin5Ziyaettin Aktop6Department of Cardiology, School of Medicine, Zonguldak Karaelmas University, Kozlu, 67600 Zonguldak, TurkeyDepartment of Immunology, Zonguldak Karaelams Univerisity, Kozlu, 67600 Zonguldak, TurkeyDepartment of Cardiology, School of Medicine, Zonguldak Karaelmas University, Kozlu, 67600 Zonguldak, TurkeyDepartment of Cardiology, School of Medicine, Zonguldak Karaelmas University, Kozlu, 67600 Zonguldak, TurkeyDepartment of Immunology, Zonguldak Karaelams Univerisity, Kozlu, 67600 Zonguldak, TurkeyDepartment of Cardiology, School of Medicine, Zonguldak Karaelmas University, Kozlu, 67600 Zonguldak, TurkeyDepartment of Cardiology, School of Medicine, Zonguldak Karaelmas University, Kozlu, 67600 Zonguldak, TurkeyBackground/Aim. Coronary artery ectasia (CAE) is considered as a variant of atherosclerosis. Tumor necrosis factor-alpha (TNF-𝛼) and interleukin-6 (IL-6) are among the sensitive markers of systemic inflammation. The aim of this study was to evaluate the plasma levels of the cytokines; TNF-𝛼 and IL-6 in CAE patients. Methods. Plasma concentrations of TNF-𝛼 and IL-6 were measured in 36 patients with CAE (28 males, mean age: 58.2±12 years), and results were compared with age and sex-matched controls (n=32) without coronary artery ectasia. TNF-𝛼 and IL-6 concentrations in blood were assesed by enzyme-linked immunosorbent assay (ELISA). Results. Baseline characteristics of the two groups were similar. TNF-𝛼 and IL-6 levels were significantly higher in CAE group than controls (15.6±11.2 pg/mL versus 7.8±3.7 pg/mL, 𝑃<.001, and 17.2±12.6 versus 7.6±2.1 𝑃<.0001, resp.). Conclusion. CAE patients showed increases in TNF-𝛼 and IL-6 levels compared to the controls. This study provides evidence for alterations in the proinflamatory cytokines which suggest the involvement of the immune system in the pathophysiology of CAE. Further placebo-controlled studies are needed to evaluate the clinical significance of this increase in TNF-𝛼 and IL-6 levels.http://dx.doi.org/10.1155/2009/106145 |
| spellingShingle | Mustafa Aydin Ishak Ozel Tekin Sait Mesut Dogan Nesligul Yildirim Mehmet Arasli Muhammet Rasit Sayin Ziyaettin Aktop The Levels of Tumor Necrosis Factor-Alpha and Interleukin-6 in Patients with Isolated Coronary Artery Ectasia Mediators of Inflammation |
| title | The Levels of Tumor Necrosis Factor-Alpha and Interleukin-6 in Patients with Isolated Coronary Artery Ectasia |
| title_full | The Levels of Tumor Necrosis Factor-Alpha and Interleukin-6 in Patients with Isolated Coronary Artery Ectasia |
| title_fullStr | The Levels of Tumor Necrosis Factor-Alpha and Interleukin-6 in Patients with Isolated Coronary Artery Ectasia |
| title_full_unstemmed | The Levels of Tumor Necrosis Factor-Alpha and Interleukin-6 in Patients with Isolated Coronary Artery Ectasia |
| title_short | The Levels of Tumor Necrosis Factor-Alpha and Interleukin-6 in Patients with Isolated Coronary Artery Ectasia |
| title_sort | levels of tumor necrosis factor alpha and interleukin 6 in patients with isolated coronary artery ectasia |
| url | http://dx.doi.org/10.1155/2009/106145 |
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