CHD7 targets active gene enhancer elements to modulate ES cell-specific gene expression.

CHD7 targets active gene enhancer elements to modulate ES cell-specific gene expression.

CHD7 is one of nine members of the chromodomain helicase DNA-binding domain family of ATP-dependent chromatin remodeling enzymes found in mammalian cells. De novo mutation of CHD7 is a major cause of CHARGE syndrome, a genetic condition characterized by multiple congenital anomalies. To gain insight...

Full description

Saved in:
Bibliographic Details
Main Authors: Michael P Schnetz, Lusy Handoko, Batool Akhtar-Zaidi, Cynthia F Bartels, C Filipe Pereira, Amanda G Fisher, David J Adams, Paul Flicek, Gregory E Crawford, Thomas Laframboise, Paul Tesar, Chia-Lin Wei, Peter C Scacheri
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2010-07-01
Series:PLoS Genetics
Online Access:https://journals.plos.org/plosgenetics/article/file?id=10.1371/journal.pgen.1001023&type=printable
Tags: Add Tag
No Tags, Be the first to tag this record!

Internet

https://journals.plos.org/plosgenetics/article/file?id=10.1371/journal.pgen.1001023&type=printable

Similar Items